Celecoxib, Gemcitabine Hydrochloride, and Cisplatin in Treating Participants with Bladder Cancer before Surgery

Inclusion Criteria

• Subjects or their legally authorized representative must be informed of the investigational nature of this study, and must sign and give written informed consent in accordance with institutional and federal guidelines
• Patients must have histologically proven urothelial carcinoma of the bladder; those with mixed histology, including a component of urothelial carcinoma, are eligible; pure small cell carcinoma, pure adenocarcinoma, and pure squamous cell carcinoma are excluded
• Patients must have stage cT2-T4a N0 M0 disease; clinical T stage is based on the transurethral resection of the bladder tumor (TURBT) sample, exam under anesthesia and cross-sectional imaging studies; patients must undergo cystoscopy and TURBT as part of the staging procedure within 120 days prior to registration; to exclude non-bulky/low-risk tumors, subjects must have documented muscle invasion with at least one of the following: * Disease measuring at least 10 mm on cross-sectional imaging; bladder thickening on imaging, by itself, is not adequate * The presence of tumor-associated hydronephrosis
• Patients must have staging scans with abdominal/pelvic computed tomography (CT) or magnetic resonance imaging (MRI) scan, and CT scan or x-ray of the chest within 56 days prior to registration; if the alkaline phosphatase is > 1.5 x upper limit of normal (ULN), there is a presence of suspicious bone pain, or if there is other clinical suspicion of bone metastases, a whole body bone scan is required within 56 days prior to registration
• Patients must have a Zubrod performance status of 0, 1 or 2
• Creatinine clearance ≥ 50 mL/min; the serum creatinine value used in the calculation must have been obtained within 28 days prior to registration using the modified Cockcroft-Gault formula
• Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (or ≤ 2.5 x ULN with Gilbert’s disease) within 28 days prior to registration
• Serum glutamic oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) ≤ 2 x institutional ULN within 28 days prior to registration
• Serum glutamic pyruvic transaminase (SGPT) (alanine aminotransferase [ALT]) ≤ 2 x institutional ULN within 28 days prior to registration
• Absolute neutrophil count (ANC) ≥ 1,500/uL within 28 days prior to registration
• Hemoglobin ≥ 9 g/dL within 28 days prior to registration
• Platelets ≥ 100,000/uL within 28 days prior to registration
• Patients must have tumor tissues from transurethral resection of the bladder tumor (TURBT) that is within 120 days of registration and available for submission; tissue sample must be sufficient for IHC testing; that is, it must be sufficient tumor tissues for correlative science after pathologic diagnosis (i.e., enough tumor tissue to pass the staging criteria)
• Patients must consent to the submission of FFPE blocks and/or unstained slides
• Patients must not have received previous systemic cytotoxic chemotherapy for urothelial carcinoma
• Patients must not have peripheral neuropathy ≥ grade 2
• Patients must not have presence of class III or IV heart failure, according to New York Heart Association classifications, or a known left ventricular ejection fraction of less than 50%; Note: left ventricular ejection fraction (LVEF) evaluation by echocardiogram or multi-gated acquisition scan (MUGA) is not required prior to registration
• Patients must not have a significant history of bleeding events * Patients with a history of a significant bleeding episode (e.g. hemoptysis, upper or lower gastrointestinal (GI) bleeding, grade 3 or 4 gross hematuria unable to be controlled by trans-urethral resection of the bladder tumor) within 6 months of registration are not eligible
• No arterial thrombotic events within 6 months of registration, including transient ischemic attack (TIA), cerebrovascular accident (CVA), peripheral arterial thrombus, unstable angina or angina requiring surgical or medical intervention in the past 6 months, or myocardial infarction (MI); patients with clinically significant peripheral artery disease (i.e., claudication on less than one block) are ineligible * Patients who have experienced a deep venous thrombosis or pulmonary embolus within the past 6 months must be on stable therapeutic anticoagulation to be enrolled to this study
• In the opinion of the treating investigator, the patient must be a candidate to receive gemcitabine/cisplatin treatment
• Patients must not have aspirin sensitive asthma
• Patients must not be known to have hypersensitivity to cisplatin, gemcitabine, or celecoxib
• Patients must not have any incidence of or uncontrolled medical illness (e.g. active cardiac symptoms, active systemic infection, etc.) that would limit the patient’s ability to participate in the protocol
• Patients must not be pregnant or nursing; women/men of reproductive potential must agree to use an effective contraceptive method during and for 6 months after completing protocol treatment; a negative pregnancy test is required within 7 days prior to registration for women of child-bearing potential
• Patients are ineligible if they plan on regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) at any dose more than 2 times per week (on average) or aspirin at more than 325 mg at least three times per week, on average; low-dose aspirin not exceeding 100 mg/day is permitted; patients who agree to stop regular NSAIDs or higher dose aspirin are eligible and no wash out period is required