CA-125 Algorithm in Early Screening for Ovarian Cancer in Low Risk Postmenopausal Participants

Inclusion Criteria

• Female, >= 50 years old and less than 75 years old
• Postmenopausal (>= 12 months amenorrhea)
• Have at least one ovary
• Cancer-free and have not received any chemotherapy or radiation therapy for >= 12 months prior to enrolling on this study
• Willingness to return for CA 125 blood tests annually or earlier if indicated
• Willingness to return to undergo transvaginal ultrasound if indicated
• Women need to provide the name of a gynecologist or qualified healthcare professional willing to provide appropriate follow-up care if indicated

Exclusion Criteria

• Psychiatric or psychological or other conditions which prevent a fully informed consent
• Prior removal of both ovaries
• Active non-ovarian malignancy
• Women who have a history of non-ovarian malignancy will be eligible if they have no persistent or recurrent disease and have not received treatment for > 12 months. If they are on selective estrogen receptor modulators (SERMS) (i.e. tamoxifen or aromatase inhibitors) they will not be excluded. Women maybe undergoing or have had treatment < 12 months prior to study entry for basal cell carcinoma only
• High risk for ovarian cancer due to known familial predisposition as defined by the following: * Known mutation in BRCA1 or BRCA2. * Two first or second degree relatives of the same lineage who have: two ovarian cancers; one ovarian cancer & one pre-menopausal breast cancer; two premenopausal breast cancers; one pre-menopausal & one post-menopausal breast cancer. (These conditions can also be met using the patient and one 1st or 2nd degree female relative.) * Ashkenazi Jewish descent with one first degree or two second degree relatives with pre-menopausal breast or ovarian cancer or participant has had pre-menopausal breast cancer. * First or second degree male relative with breast cancer diagnosed at any age. (First degree relative defined as children, siblings, and parents. Second degree relative defined as half-siblings, aunts, uncles, nieces, nephews, grandparents, and grandchildren.)
• Hereditary nonpolyposis colorectal cancer (HNPCC)/Lynch Syndrome: known genetic mutation, presumed HNPCC carrier, Amsterdam criteria
• Female: Less than 50 years old or older than 75 years at the time of enrollment