General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

Status: complete

This is a large pragmatic multicenter trial comparing maintenance of general anesthesia with total intravenous anesthesia using propofol versus volatile agent (sevoflurane, isoflurane, or desflurane) during cancer surgery. The primary endpoint is all-cause mortality.

Inclusion Criteria

Patients with known or suspected cancer and scheduled to undergo any of the following oncologic surgical procedures:
Lobectomy or pneumonectomy
Esophagectomy
Radical (total) cystectomy
Pancreatectomy
Partial hepatectomy
Hyperthermic intraperitoneal chemotherapy (HIPEC)
Gastrectomy (subtotal or total)
Cholecystectomy or bile duct resection

Exclusion Criteria

Age less than 18 years
American Society of Anesthesiologist Class 5
Projected life expectancy less than 30 days
Known or suspected hypersensitivity to either propofol, e.g. egg or soy allergy, or volatile general anesthetic agents
Known or suspected history of malignant hyperthermia

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General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial

Description

Eligibility Criteria

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