Dietary Intervention in Patients with a History of Melanoma

Inclusion Criteria

• Melanoma resected within the last 5 years, currently no evidence of disease (NED) and not on systemic therapy.
• Body mass index (BMI) 18.5-40 kg/m^2.
• English-speaking.
• Self-reported willingness to exclusively eat the provided diets.
• Self-reported willingness to comply with scheduled visits, undergo venipuncture, provide stool samples.
• Creatinine (Cr) < 1.5 mg/dL.
• Liver function tests (LFTs) 2 x upper limit of normal (ULN).
• Fasting glucose < 125 mg/dL.
• Women of child-bearing (WOCP) potential must have negative urine pregnancy test (UPT) within 1 week prior to dual x-ray absorptiometry (DEXA) scan.

Exclusion Criteria

• Systemic treatment for melanoma within the past 1 year.
• Medical contraindications to the intervention diet as determined by the treating physician.
• Self-reported major dietary restrictions related to the intervention.
• Diagnosis of diabetes mellitus type I or type II that requires medical treatment.
• Unable or unwilling to undergo study procedures.
• Antibiotic use within the last 30 days (self-reported and/or noted by the treating physician).
• Regularly taking probiotics, fiber supplements, or bile acid sequestrants, exogenous ketones, weight loss supplements, appetite suppressants, carnitine supplements, creatine supplements or diuretics within the last 30 days (self-reported and/or noted by the treating physician).
• Currently following a ketogenic diet with > 70% calories derived from fat or consuming > 40 grams of fiber per day or a vegetarian or vegan diet.
• Current self-reported smoker or heavy drinker (defined as > 14 drinks per week) or current self-reported illicit drug use.
• Pregnant or lactating.
• Low density lipoprotein (LDL) > 200 mg/dL (within 28 days of screening).
• Triglycerides > 350 mg/dL (within 28 days of screening).