Physical Activity Intervention in Improving Exercise Capacity in Stage I-IV Lymphoma or Stage I-III Breast Cancer Patients Undergoing Treatment

PRIMARY OBJECTIVES:

I. To provide critical participant enrollment data necessary to accomplish the R01 submission, including:

Ia. Feasibility of screening, enrolling, and randomizing 18 non or Hodgkin lymphoma or breast cancer patients including the reasons for failed randomization.

Ib. Identification of barriers for participating in or adhering to the physical activity intervention (PAI) and the health living intervention (HLI) control group via qualitative interviews.

SECONDARY OBJECTIVE:

I. In these 18 patients, at study initiation then 3 and 6 months after initiating interventions, to assess the ability to ascertain: peak exercise cardiac output, calculated arteriovenous (A-V) oxygen (O2) difference and oxygen consumption (VO2), and pre- exercise measures of left ventricular (LV) & cognitive function, health-related quality of life (HRQOL), six-minute walk distance (6 min WD) and fatigue.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I (PHYSICAL ACTIVITY): Patients participate in online exercise training sessions at least 1-2 sessions over 45-60 minutes per week on Mondays, Wednesdays, and Fridays weekly and 1-2 sessions over 45-60 minutes per week at home for 6 months. Patients are encouraged to accumulate 150 minutes of light-moderate intensity physical activity per week outside the program facility. Patients also wear a Fitbit and actigraph to monitor physical activity.

ARM II (HEALTHY LIVING): Patients participate in online or in-person health workshops focused on proper nutrition, management of stress, sleep practices, and upper body stretching over 60 minutes each 2 times monthly for 6 months.