This trial studies how fiber and fish oil supplements affect the metabolism and activities of colon cells in healthy individuals. Diet is an important risk factor for colorectal cancer, and several dietary components important in colorectal cancer prevention are modified by gut microbial metabolism. Giving fiber and fish oil supplements may inhibit the growth of gut cells and ultimately reduce risk of colorectal cancer.
Additional locations may be listed on ClinicalTrials.gov for NCT04211766.
See trial information on ClinicalTrials.gov for a list of participating sites.
PRIMARY OBJECTIVES:
I. To determine whether the combination of supplemental dietary fiber and eicosapentaenoic acid (EPA) + docosahexaenoic (DHA) from fish oil versus (vs) placebo affects messenger ribonucleic acid (mRNA) expression in exfoliated colonic cells.
II. To determine whether gut microbial functional capacity related to fiber fermentation, as measured by presence of fiber-fermenting genes in stool bacteria, alters exfoliome mRNA expression response to the intervention.
OUTLINE: Participants are randomized to receive two dietary interventions in assigned random order. They either receive the dietary fiber supplement and fish oil supplement orally (PO) daily or they receive a fiber control and corn oil supplement daily for 30 days during the first intervention period. Then they enter a washout period for 60 days when they do not receive any treatment. After that they complete the second intervention period during which they receive the other intervention.
Lead OrganizationFred Hutch/University of Washington/Seattle Children's Cancer Consortium
Principal InvestigatorJohanna Lampe
