Acalabrutinib for the Treatment of Ibrutinib-Intolerant Mantle Cell Lymphoma

Inclusion Criteria

• Confirmed diagnosis of mantle cell lymphoma with CD20 positivity and chromosome translocation t(11;14), (q13;q32) and/or overexpress cyclin D1 in tissue biopsy. Patients who have had a bone marrow aspirate (BMA)/bone marrow (BM) biopsy (Bx) and/or gastrointestinal (GI) endoscopy and biopsy and/or tissue biopsy performed and confirming MCL at MD Anderson Cancer Center (MDACC) within 42 days prior to screening do not need to repeat the invasive procedure at screening
• Include patients who require treatment (versus watch/wait) or patients who are in complete remission on ibrutinib/BTK inhibitor maintenance therapy or those who require maintenance therapy and had discontinued ibrutinib/BTK inhibitor earlier for reasons other than progression/relapse
• Prior treatment with ibrutinib discontinued for reasons other than progression
• Patients who were on ibrutinib-rituximab maintenance and who develop ibrutinib associated toxicities/ibrutinib associated reasons for discontinuation (other than disease progression) are allowed to continue rituximab and SWITCH to acalabrutinib
• Intolerance is defined as unacceptable or intolerable toxicity, [where, in the opinion of the investigator, treatment should be discontinued in spite of optimal supportive care (including management according to ibrutinib basic prescribing information)] defined as one of the following: * 2 or more grade >= 2 non-hematological toxicities; OR * 1 or more grade 3 >= 3 non-hematological toxicity; OR * 1 or more grade 3 neutropenia with infection or fever; OR, * Grade 4 hematologic toxicity which persists to the point that the investigator chose to stop therapy due to toxicity NOT progression ** Toxicity must have resolved to =< grade 1 prior to acalabrutinib dosing
• Understand and voluntarily sign an Institutional Review Board (IRB)-approved informed consent form
• Age >= 18 years at the time of signing the informed consent
• Patients who are in complete response or partial response while taking another BTK inhibitor such as ibrutinib but had to discontinue due to intolerance are eligible even in the absence of measurable disease to maintain the achieved response
• Bi-dimensional measurable disease using the Cheson 2014 criteria or Lugano criteria (measurable disease by positron emission tomography [PET]-computed tomography [CT] scan defined as at least 1 lesion that measures >= 1.5 cm in single dimension). Gastrointestinal, bone marrow or spleen only patients are allowable
• Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less
• Absolute neutrophil count (ANC) > 1,000/mm^3 * Patients who have bone marrow infiltration by mantle cell lymphoma (MCL) are eligible if their ANC is >= 500/mm^3 (growth factor allowed) or their platelet level is equal to or > 20,000/mm^3. These patients should be discussed with either the principal investigator (PI) or co-PI of the study for final approval
• Platelet count > 75,000/mm^3 * Patients who have bone marrow infiltration by MCL are eligible if their ANC is >= 500/mm^3 (growth factor allowed) or their platelet level is equal to or > 20,000/mm^3. These patients should be discussed with either the PI or co-PI of the study for final approval
• Serum bilirubin < 1.5 mg/dl
• Creatinine (Cr) clearance minimum to 30 mL/min per the Cockcroft-Gault formula as acalabrutinib pharmacokinetic (PK) has not been evaluated in patients with severe renal impairment (estimated glomerular filtration rate [eGFR] < 29 mL/min/1.7 3^m2, MDRD) or renal impairment requiring dialysis
• Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) < 2.5 x upper limit of normal or < 5 x upper limit of normal if hepatic metastases are present. Gilbert’s disease is allowed
• Disease free of prior malignancies with exception of currently treated basal cell, squamous cell carcinoma of the skin, carcinoma "in situ" of the cervix or breast, or other malignancies in remission (including prostate cancer patients in remission from radiation therapy, surgery or brachytherapy), not actively being treated with life expectancy of > 3 years. PI can use clinical judgement in the best interest of patients
• Women of childbearing potential (WOBP) must have a negative serum or urine pregnancy test. WOBP and males must be willing to use highly effective methods of birth control prior to starting therapy. Woman of childbearing potential (WOCBP) who are sexually active must use highly effective methods of contraception during treatment and for one week after the last dose of acalabrutinib. For male subjects with a pregnant or non-pregnant WOCBP partner, should use barrier contraception even if they have had a successful vasectomy
• Patients who were not placed originally on ibrutinib by the providers due to concerns for worsening of comorbidities due to ibrutinib, such as atrial fibrillation can be included after cardiology clearance

Exclusion Criteria

• Prior treatment with acalabrutinib
• History of BTK mutations conferring resistance to BTK inhibitors. Known mutations in the BTK gene that confer resistance to ibrutinib in mantle cell lymphoma include (e.g. BTK C481S, C481R mutations)
• Progressive disease while on ibrutinib therapy. Patients who progressed while on ibrutinib therapy will be excluded from the study, patients who discontinue ibrutinib due to anaphylaxis or hypersensitivity reaction related to ibrutinib will be excluded from participation in the study
• Known history of drug-specific hypersensitivity or anaphylaxis to ibrutinib (including active product or excipient components)
• Pregnant or breast-feeding females
• Patients with human immunodeficiency virus (controlled or uncontrolled infection)
• Patients with active hepatitis B infection. Those with prior hepatitis (hep)-B vaccination (i.e., anti-HBs antibody positive) or natural immunity as evidenced by the presence of anti-HBs and anti-HBc positivity are eligible to enroll. (Known hepatitis C infection is allowed as long as there is no active disease and is cleared by gastrointestinal [GI] consultation)
• Patients with central nervous system involvement with mantle cell lymphoma or with suspected or confirmed progressive multifocal leukoencephalopathy (PML) are excluded since those patients have very poor prognosis, need aggressive intensive chemoimmunotherapy and intrathecal chemotherapy along with BTK inhibitors and these patients would not be eligible for single agent acalabrutinib as proposed in this study
• Active bleeding, history of bleeding diathesis (such as hemophilia or Von-Willebrand disease), Any history of intracranial bleed or stroke within 6 months of first dose of study drug
• Uncontrolled AIHA (autoimmune hemolytic anemia) or ITP (idiopathic thrombocytopenic purpura)
• Ongoing adverse events from prior ibrutinib therapy (except persistent hematologic toxicity if meeting entry criteria). The PI should determine if AEs are an ongoing sequel of prior BTK therapy such as fungal infections, skin rash, diarrhea, fatigue, cramps and colitis or if the patient has resolved AE up to grade 1 or less should be allowed, after stopping ibrutinib)
• Malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel or ulcerative colitis, symptomatic inflammatory bowel disease, or partial or complete bowel obstruction, or any other gastrointestinal condition that could interfere with the absorption and metabolism of acalabrutinib
• Presence of a gastrointestinal ulcer diagnosed by endoscopy within 3 months before first dose of study drug
• Major surgery within 4 weeks of initiation of therapy
• Requires anticoagulation with warfarin or equivalent vitamin K antagonist
• Concomitant use of corticosteroids at up to 20 mg prednisone or equivalent per day for more than 2 weeks
• Requires treatment with strong CYP3A inhibitors or inducers. The use of strong CYP3A inhibitors within 1 week or strong CYP3A inducers within 3 weeks of the first dose of study drug is prohibited
• Any of the following cardiac related conditions: * New York Heart Association (NYHA) class III and IV heart failure, * Active/symptomatic coronary artery disease, * Myocardial infarction in the preceding 6 months, * Significant conduction abnormalities, including but not limited to: ** Left bundle branch block, ** 2nd degree atrioventricular (AV) block type II, ** 3rd degree block, ** QT prolongation (corrected QT interval [QTc] > 500 msec), ** Sick sinus syndrome, ** Ventricular tachycardia, ** Symptomatic bradycardia (heart rate < 50 bpm), ** Persistent and uncontrolled atrial fibrillation. * Uncontrolled hypertension, * Hypotension, * Light headedness and syncope
• Acute infection requiring systemic anti-microbial treatment (systemic antibiotics, antivirals, or antifungals) within 14 days prior to initiation of therapy. Including subjects with positive cytomegalovirus (CMV) deoxyribonucleic acid (DNA) polymerase chain reaction (PCR)
• Requires treatment with proton-pump inhibitors (e.g., omeprazole, esomeprazole, lansoprazole, dexlansoprazole, rabeprazole or pantoprazole). Subjects receiving proton-pump inhibitors who switch to H2-receptor antagonists or antacids are eligible for enrollment to this study
• Any other serious medical condition including, but not limited to, uncontrolled diabetes mellitus, chronic obstructive pulmonary disease (COPD), renal failure, psychiatric illness or social circumstances that, in the investigator’s opinion places the patient at unacceptable risk and would prevent the subject from signing the informed consent form or complying with study procedures
• Received a live virus vaccination within 28 days of first dose of study drug
• Concurrent participation in another therapeutic clinical trial