This trial studies how well exercise with creatine supplementation works in improving the ability to perform exercise training in breast cancer survivors. Individuals with cancer are at high risk for skeletal muscle wasting that may be made worse by cancer treatment or tumor-related factors. Creatine, a naturally occurring substance in the body, may increase training adaptations such as improved strength and physical function. Increasing creatine may help cancer survivors respond quicker to exercise by improving strength, endurance, and body composition.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT04207359.
PRIMARY OBJECTIVES:
I. Determine the effects of creatine in modulating strength and physical function in cancer survivors.
II. Determine if supplemental creatine can increase intramuscular storage of creatine and alter energy storage.
III. Test the hypothesis that creatine supplementation will improve body composition in cancer survivors.
OUTLINE: Patients are randomized to 1 of 2 groups.
GROUP I: Patients participate in virtual exercise sessions over 1 hour (with a 10 minute warm up and 50 minute stimulus phase) 3 times a week for 12 weeks. Patients also receive creatine supplementation orally (PO) daily for 12 weeks.
GROUP II: Patients participate in virtual exercise sessions over 1 hour (with a 10 minute warm up and 50 minute stimulus phase) 3 times a week for 12 weeks.
Trial PhaseNo phase specified
Trial Typebasic science
Lead OrganizationCancer Therapy and Research Center at The UT Health Science Center at San Antonio
Principal InvestigatorDarpan Patel
