KEYMAKER-U01 Umbrella Master Study: Studies of Investigational Agents With Either Pembrolizumab (MK-3475) Alone or With Pembrolizumab PLUS Chemotherapy in Participants With Non-small Cell Lung Cancer (NSCLC) (MK-3475-U01/KEYMAKER-U01)

The following pembrolizumab substudies will evaluate the efficacy of different

investigational agents in combination with pembrolizumab given in sequence or in

combination with pembrolizumab PLUS chemotherapy:

- KEYMAKER-U01 Substudy 01A: A Phase 1/2, Umbrella Study With Rolling Arms of

Investigational Agents, With Pembrolizumab With or Without Chemotherapy in

Treatment-Naive Participants With Stage IV Non-small Cell Lung Cancer (NSCLC)

(MK-3475-01A) - NCT04165070

- KEYMAKER-U01 Substudy 2: A Phase 2, Umbrella Study with Rolling Arms of

Investigational Agents in Combination with Pembrolizumab in Treatment Naïve Patients

with PD-L1 Positive Advanced Non-small Cell Lung Cancer (NSCLC) (MK-3475-01B) -

NCT04165083

- KEYMAKER-U01 Substudy 3: A Phase 2, Umbrella Study with Rolling Arms of

Investigational Agents in Combination with Pembrolizumab in Patients with Advanced

Non-small Cell Lung Cancer (NSCLC) Previously Treated with anti-PD-(L)1 Therapy

(MK-3475-01C) - NCT04165096

- KEYMAKER-U01 Substudy 01E: A Phase 2 Umbrella Study With Rolling Arms of

Investigational Agents With or Without Chemotherapy in Combination With

Pembrolizumab in Treatment of Participants With Newly Diagnosed Resectable Stages

II-IIIB (N2) Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E) - NCT06788912

- KEYMAKER-U01 Substudy 01F: A Phase 1b/2 Umbrella Study With Rolling Arms of

Investigational Agents for Second-line Treatment of Participants With Advanced or

Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With KRAS G12C Mutations

(MK-3475-01F) - NCT number pending

- KEYMAKER-U01 Substudy 01G: A Phase 2, Umbrella Study With Rolling Arms of

Investigational Agents in Combination With Pembrolizumab With or Without

Platinum-based Chemotherapy in Treatment-Naïve Participants With Stage IV Non-small

Cell Lung Cancer (NSCLC) (MK-3475-01G) - NCT06731907

- KEYMAKER-U01 Substudy 01H: A Phase 2, Randomized, Umbrella Study With Rolling Arms

of Investigational Agents in Participants with Previously Treated Stage IV

Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H) - NCT06780085

- KEYMAKER-U01 Substudy 01I: A Phase 2, Randomized, Umbrella Study With Rolling Arms

of Investigational Agents in Participants With Previously Treated Stage IV Squamous

Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I) - NCT06780098

- KEYMAKER-U01 Substudy 01J: A Randomized Phase 2 Umbrella Study With Rolling Arms of

Investigational Agents for First-line Treatment of Participants With Advanced or

Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With KRAS G12C Mutations

(MK-3475-01J) - NCT number pending