A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma
The purpose of this study is to identify recommended Phase 2 doses (RP2Ds) for each treatment combination (between daratumumab plus talquetamab and teclistamab plus daratumumab with or without pomalidomide) and to characterize the safety of each RP2D for selected treatment combinations.
Inclusion Criteria
- Documented initial diagnosis of multiple myeloma according to International Myeloma Working Group (IMWG) diagnostic criteria
- Must have either of the following: a) received at least 3 prior lines of therapy including a proteasome inhibitor (PI) (greater than or equal to [>=] 2 cycles or 2 months of treatment) and an immunomodulatory drug (IMiD) (>=2 cycles or 2 months of treatment) in any order during the treatment or b) disease that is double refractory to a PI and an IMiD
- Measurable disease at screening as defined by any of the following: Serum monoclonal protein (M-protein) level >=1.0 grams per deciliter (g/dL) (in non- immunoglobulin G (IgG) myeloma, an M-protein level >=0.5 g/dL); or Urine M-protein level >=200 milligrams (mg)/24 hours; or Light chain multiple myeloma: Serum immunoglobulin (Ig) free light chain (FLC) >=10 milligrams per deciliter (mg/dL) and abnormal serum Ig kappa lambda FLC ratio
- Eastern Cooperative Oncology Group (ECOG) performance status grade of 0 or 1 at screening and at Cycle 1, Day 1 predose
- Female participants of childbearing potential must have a negative highly-sensitive serum beta-human chorionic gonadotropin (beta-hCG) pregnancy test (less than [<] 5 international units per milliliter [IU/mL]) at screening and a negative urine or serum pregnancy test within 1 day before the first dose of study drug
Exclusion Criteria
- Treatment in the prior 3 months with an anti- cluster of differentiation 38 (CD38) therapy (example, daratumumab), or discontinuation of a prior anti-CD38 therapy at any time due to an adverse event related to the anti-CD38 therapy
- Live, attenuated vaccine within 4 weeks prior to the first dose of study drug unless approved by sponsor
- Active Central nervous system involvement or exhibits clinical signs of meningeal involvement of multiple myeloma. If either is suspected, brain magnetic resonance imaging (MRI) and lumbar cytology are required
- Seropositive for hepatitis B (defined by a positive test for hepatitis B surface antigen [HBsAg]). Participants with resolved infection must be screened using real-time polymerase chain reaction (PCR) measurement of hepatitis B virus (HBV) deoxyribonucleic acid (DNA) levels. Those who are PCR positive will be excluded
- Active hepatitis C infection as measured by positive hepatitis C virus- ribonucleotide (HCV)-RNA testing. Participants with a history of Hepatitis C virus antibody positivity must undergo HCV-RNA testing
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT04108195.
Multiple myeloma is a malignant plasma cell disorder characterized by osteolytic lesions,
increased susceptibility to infections, hypercalcemia, and renal failure. Overall
rationale of study is that daratumumab in combination with talquetamab or teclistamab
with or without pomalidomide may lead to enhanced clinical responses in treatment of
relapsed or refractory multiple myeloma through multiple mechanisms of action.
Daratumumab is human immunoglobulin G1 kappa monoclonal antibody (IgG1k) that binds with
high affinity to a unique epitope on cluster of differentiation 38 (CD38) in a variety of
hematological malignancies including multiple myeloma. Talquetamab and teclistamab are
bispecific T cell redirection antibodies. Talquetamab binds to cluster of differentiation
3 (CD3) receptor complex on T cells and to G protein-coupled receptor family C group
5-member D (GPRC5D), a 7-transmembrane receptor protein on plasma cells and teclistamab
binds to human and cynomolgus-CD3 and B cell maturation antigen (BCMA). Purpose of study
is to evaluate safety of daratumumab in combination with talquetamab and teclistamab with
or without pomalidomide, and to evaluate preliminary antitumor activity of each
combination. Study consists of a screening period, treatment period (Part 1: dose
escalation and Part 2: dose expansion), a Post-treatment Follow-up Period (after the last
dose of study drug and will continue for up to 16 weeks for each subject), and a
Long-term Extension Period. The study will end when one of the following occurs: 1) the
study drug has received marketing authorization and, if regionally applicable, government
reimbursement is available; 2) a long-term extension rollover study has commenced for
participants who are still benefiting from study treatment as determined by their
investigator; or 3) all participants have discontinued study treatment. Total duration of
study is approximately 5 years and 6 months. Efficacy, safety, pharmacokinetics (PK),
immunogenicity, and biomarkers will be assessed at specified time points. Participants
safety will be monitored throughout study by Study Evaluation Team (SET). SET consists of
members of sponsor's study team and participating investigators.
Trial PhasePhase I
Trial Typetreatment
Lead OrganizationJanssen Research & Development, LLC
- Primary IDCR108620
- Secondary IDsNCI-2020-00281, 2019-000330-19, 2023-503468-17-00, 64407564MMY1002
- ClinicalTrials.gov IDNCT04108195