This study will collect tumor samples from people with cancers of the blood, bone marrow,
or lymph glands for laboratory study of the biology of these conditions. Such studies
contribute to a better understanding of cancer biology and to the development of new
treatments. Planned studies include:
- Examination of individual cancer cells and to search for differences compared to
other types of cancer and normal cells
- Examination of the chromosomes and genes in cancer cells and to search for
differences compared to other types of cancer and normal cells
- Development of sensitive methods to detect small amounts of cancer that remain after
treatment
- Search for new cancer proteins that might serve as targets for treatment
- Investigation of methods to develop cancer vaccines.
Patients from >= 1 to 75 years of age with acute lymphocytic leukemia, acute myelogenous
leukemia, myelodysplastic syndrome, chronic myelogenous leukemia, juvenile myelomonocytic
leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, and other hematologic malignancies
may be eligible for this study.
Blood or bone marrow samples will be collected when sampling is required for the
patient's medical care. Cells from some individuals will be grown in test tubes,
establishing cell lines or in animals, establishing xenograft models. (A xenograft is
transplantation of cells of one species to another species.)
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT00923442.
Locations matching your search criteria
United States
Maryland
Bethesda
National Institutes of Health Clinical CenterStatus: Enrolling By Invitation
Contact: National Cancer Institute Referral Office
Phone: 888-624-1937
Background:
Laboratory-based investigations have contributed to an improved understanding of
pathophysiology and to the development of new therapies for hematologic malignancies.
The aim of this protocol is to facilitate biologic study of leukemias, pre-malignant
conditions, myelodysplastic syndromes, lymphomas, and other blood disorders.
This is a sample acquisition protocol for targeted study of hematologic malignancies by a
collaborative network of NIH investigators from multiple Institutes/Centers.
Objective:
This biology protocol is designed to allow sample acquisition for use in the study of
hematologic malignancies. A variety of laboratory investigations designed to support NIH
translational trials, to apply new methodologies in the study of cellular, and molecular
biology, to probe for new therapeutic targets; and to develop new treatment approaches
will be performed.
Eligibility:
Diagnosis of any hematologic malignancy or pre-malignant conditions, including but not
restricted to the following: Acute Lymphocytic Leukemia (ALL), Acute Myelogenous Leukemia
(AML), Myelodysplastic Syndrome (MDS), Chronic Myelogenous Leukemia (CML), Juvenile
Myelomonocytic Leukemia (JMML, J-CML), Non-Hodgkin s Lymphoma (NHL), Hodgkin s Disease
Tumor tissue that has been previously collected and is available for study or that can be
collected with minimal additional risk to the subject during sampling required for
routine patient care.
Patient age: >= 1 year
Design:
Biologic assays relevant to the investigation of hematologic malignancies will be
performed in an exploratory fashion, some studies are developmental, i.e., assay design
in support of current or planned CC clinical trials. Others are standard assays that will
be applied in attempt to identify new targets or test new therapeutic approaches.
.
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationNational Cancer Institute
Principal InvestigatorNirali N. Shah
