Medical and Psychosocial Issues in Adolescents and Young Adults with Colorectal Cancer

Status: closed to accrual and intervention

This clinical trial investigates the medical and psychosocial consequences of colorectal cancer on adolescents and young adults. Measuring physical function in adolescents and young adults with colorectal cancer may help doctors better understand the level of physical function during cancer treatment and how to improve the management of colorectal cancer in adolescents and young adults. This study may also help design a future exercise program to decrease risk factors including high blood pressure, high blood sugar, and high cholesterol.

Inclusion Criteria

Diagnosis of colorectal cancer (any stage)
Any type of prior therapy
Age >= 18-39 years for AYA/young adult sample, age 40+ for older comparison group
For patients on active therapy: must have been diagnosed within the past three months. For survivors: must have completed curative therapy and are 6-24 months post-diagnosis
Speak English or Spanish
Ability to understand and the willingness to sign a written informed consent
For substudy: Patients must currently be on an oxaliplatin-based regimen

Exclusion Criteria

Patients who are more than 3 months from diagnosis, and survivors who are more than 36 months from initial diagnosis
Patients who have a life expectancy of less than 6 months per their medical oncologist
Patients who are deemed too ill or unable to participate by their medical oncologist (e.g., have cognitive impairment or brain metastases)
Patients who do not speak English or Spanish

PRIMARY OBJECTIVES:

I. To prospectively characterize the symptom burden and assess the health-related quality of life of adolescents and young adults (AYAs) in active treatment for colorectal cancer in comparison to older patients to identify differences that contribute to the development of appropriately timed, age appropriate interventions.

II. To characterize the symptom burden and assess the health-related quality of life of AYAs who have completed curative therapy and are in surveillance for colorectal cancer compared to older patients to identify differences that contribute to the development of appropriately timed, age-appropriate interventions.

SECONDARY OBJECTIVE:

I. To examine correlations between dynamic changes of oral microbiota composition and psychosocial outcomes among 30 colorectal cancer patients (15 younger adults aged 18-39, and 15 aged 40-64) currently on oxaliplatin-based chemotherapy.

EXPLORATORY OBJECTIVE:

I. To assess across Aims differences by cancer site (colon versus [vs.] rectal) by sex, and by race/ethnicity.

OUTLINE:

Patients on active treatment complete questionnaires and undergo collection of blood samples and physical function assessments at baseline, and at 3 and 6 months. Survivors in surveillance complete questionnaires and undergo collection of blood sample and physical function assessment at baseline.

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Medical and Psychosocial Issues in Adolescents and Young Adults with Colorectal Cancer

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