Prospective Exploratory Study of FAPi PET/CT in Prostate Cancer with Histopathology Validation

This exploratory study investigates how a new imaging technique called FAPI PET/CT can determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues in patients with prostate cancer. Because some cancers take up 68Ga-FAPi-46 it can be seen with PET. FAP stands for Fibroblast Activation Protein. FAP is produced by cells that surround tumors. The function of FAP is not well understood but imaging studies have shown that FAP can be detected with FAPI PET/CT. Imaging FAP with FAPI PET/CT may in the future provide additional information about various cancers including prostate cancer.

Additional locations may be listed on ClinicalTrials.gov for NCT04457232.

See trial information on ClinicalTrials.gov for a list of participating sites.

Trial PhasePhase O

Trial Typebasic science

Lead OrganizationUCLA / Jonsson Comprehensive Cancer Center

Principal InvestigatorJeremie Calais

• Primary ID20-000177
• Secondary IDsNCI-2020-02712
• ClinicalTrials.gov IDNCT04457232