Contrast-Enhanced CBCT during Radiation Therapy in Patients with Abdominal or Pelvic Tumors

Inclusion Criteria

• Ability to understand and the willingness to sign a written informed consent document
• Subject requiring image-guided external beam radiotherapy to abdominal or pelvic tumor with cone beam CT deemed clinically necessary by the treating physician
• No history of prior allergic reaction to intravenous CT contrast medium
• Creatinine of less than 1.9 mg/dL measured within one month prior to enrollment on the study
• No administration of intravenous contrast within 24 hours of administration of intravenous contrast on protocol
• Ability to complete New York-Presbyterian Hospital iodinated contrast media administration questionnaire
• Negative pregnancy test for females of childbearing potential, in accordance to institutional guidelines
• Ability to fast for at least 2 hours prior to study procedures
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-3

Exclusion Criteria

• Known allergy to iohexol or any iodinated intravenous contrast medium
• Fluid overload that would contraindicate bolus administration of intravenous contrast
• Pregnant or nursing subjects
• Presence of single kidney or transplanted kidney
• Acute renal failure
• Chronic renal insufficiency, stage IV or V
• Administration of iodinated intravenous CT contrast medium within 24 hours of study procedures
• Inability to fast for at least 2 hours prior to study procedures