This trial studies the side effects of multispectral optoacoustic tomography and how well it may work in diagnosing patients with solid tumors and positive lymph nodes. Imaging is important in the management of all cancer types, including intraoperative identification of surgical margins and evaluation of tumor-positive lymph nodes. Multispectral optoacoustic tomography uses a “light-in and sound-out” approach which specifically includes a laser and ultrasound detector to study the tissue. This method may improve the detection of tumor and tumor affected lymph nodes compared to current methods.
Additional locations may be listed on ClinicalTrials.gov for NCT04365413.
See trial information on ClinicalTrials.gov for a list of participating sites.
PRIMARY OBJECTIVES:
I. To collect safety data on patients in whom multispectral optoacoustic tomography (MSOT) was used to image tumor or lymph nodes.
II. To evaluate skin temperature pre and post imaging (pre- and post-surgery) as part of the safety evaluation of MSOT.
SECONDARY OBJECTIVES:
I. To detect tumor or lymph node by MSOT before and after surgical removal.
II. To determine tumor positivity based on tissue pathology and detection of oxy- and deoxy-hemoglobin using MSOT localization.
III. To determine tumor volume by MSOT before and after surgical resection.
OUTLINE:
Patients undergo MSOT imaging over 3-5 minutes before and after standard of care surgical resection of solid tumor or positive lymph node.
After completion of study, patients are followed up by medical record review for up to 6 months.
Trial PhaseNo phase specified
Trial Typediagnostic
Lead OrganizationUniversity of Oklahoma Health Sciences Center
Principal InvestigatorLacey McNally
