Diffusion Basis Spectrum Imaging of the Prostate to Accurately Diagnose Prostate Cancer

Inclusion Criteria

• Over 18 years of age and willing and able to provide informed consent
• Patients with no prior diagnosis of PCa, who are planning to undergo prostate biopsy as clinical standard of care (“early detection cohort”) * Including those men with: ** An elevated prostate specific antigen (PSA) and no prior biopsy ** An elevated PSA and a negative prior biopsy
• Patients with a prior diagnosis of PCa, who are currently managed with active surveillance, who are planning to undergo biopsy as clinical standard of care (“active surveillance cohort”)

Exclusion Criteria

• Patients with any clinical contraindication to MRI * Including but not limited to: ** Those with metallic implants, such as pacemakers or implantable cardioverter-defibrillators ** Those with cochlear implants ** Those with claustrophobia not relieved with medications (patients with claustrophobia who do not need medications for the scan or whose claustrophobia can be managed with medication, are eligible to participate) ** Those who cannot lie flat for over 1 hour
• Patients with prior prostate surgery for prostate cancer (e.g. radical prostatectomy, focal ablation)