Laser Interstitial Thermal Therapy and Hypofractionated Radiation Therapy for the Treatment of Recurrent or Progressive Grade II-IV Glioma

Inclusion Criteria

• Patients with history of a World Health Organization (WHO) grade II-IV glioma with radiographic evidence of recurrent or progressive tumor * Patient must have received prior radiation therapy for initial treatment of glioma * Patients with any number of recurrences are allowed as long as the patient has not undergone re-irradiation
• Brain magnetic resonance imaging (MRI) with contrast demonstrates an enhancing tumor =< 6 cm in largest diameter within 60 days prior to registration
• History and physical including neurological exam within 30 days prior to registration
• Karnofsky performance status >= 60% within 30 days prior to registration
• Age >= 18 years old
• Minimum interval since completion of prior radiation treatment is 8 weeks * Patients will only receive re-irradiation if pathology from LITT is consistent with recurrent tumor
• Patient or legally authorized representative (LAR) must have signed an approved informed consent
• Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion
• Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration

Exclusion Criteria

• Patients that are not surgical candidates for stereotactic biopsy or laser ablation
• Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following: * History or presence of serious uncontrolled ventricular or significant arrhythmias * Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism
• Infratentorial tumor or evidence of leptomeningeal spread
• Inability to undergo a MRI
• Pregnant or breast-feeding women