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89Zr-DFO-REGN3767 in PET Scans in People with Diffuse Large B Cell Lymphoma

Trial Status: complete

This phase I/II trial evaluates 89Zr-DFO-REGN3767 in diagnosing patients with diffuse large B cell lymphoma that has come back (relapsed) or does not respond to treatment (refractory). 89Zr-DFO-REGN3767 is an antibody agent—an antibody to which a tiny amount of radioactivity is attached. An antibody is a protein made by the immune system to help fight infections and other harmful processes/cells/molecules. The antibody part of 89Zr-DFO-REGN3767 attaches to the LAG-3 protein on tumor cells. The PET scans help doctors to see where 89Zr-DFO-REGN3767 goes in the body. 89Zr-DFO-REGN3767 may help researchers find tumors that make (express) LAG-3 and identify cancer patients who will benefit from cancer-fighting drugs that target LAG-3.