This trial evaluates high-resolution magnetic resonance imaging (HR-MRI) and ultrasound elastography in detecting peritoneal mesothelioma. For cancers, such as mesothelioma, that spread to the lining of the abdomen, detecting the cancer is very difficult with computed tomography (CT) or MRI scans. Diagnostic procedures, such as HR-MRI and ultrasound elastography, may help find and diagnose peritoneal mesothelioma better than standard MRI.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT03867578.
PRIMARY OBJECTIVES:
I. To prospectively determine the optimal HR-MRI strategy from the exploratory phase (5 patients) in patients from the University of Chicago Medicine with peritoneal disease from mesothelioma in whom surgery is planned.
II. To determine the proportion of patients with disease that is detectable on standard CT imaging.
III. To validate performance of diffusion-weighted MRI in detecting peritoneal disease in patients with malignant peritoneal mesothelioma (MPM).
IV. To test high-definition small-voxel MRI imaging (HR-MRI) sequences for detection of peritoneal disease in MPM, focusing on the right hemidiaphragmatic and pelvic spaces.
V. To perform ultrasound elastography in peritoneal mesothelioma (PM) patients to determine optimal strain ratios and elasticity scores to maximize sensitivity in this population.
OUTLINE:
Patients undergo standard of care CT. After at least 24 hours, patients then receive gadolinium intravenously (IV) and undergo HR-MRI over 1-1.5 hours and ultrasound elastography over 30 minutes.
Trial PhaseNo phase specified
Trial Typediagnostic
Lead OrganizationUniversity of Chicago Comprehensive Cancer Center
Principal InvestigatorKiran K. Turaga
