This study identifies molecular and epidemiological risk factors in the development of gastric cancer in high-risk predominantly Hispanic population. Gastric cancer affects more Hispanics than non-Hispanic people for unknown reasons and it is unclear if this phenomenon is due to differences in genetic factors or exposure to environmental risk factors. Hispanics with gastric cancer also present at a younger age and with more advanced disease than their non-Hispanic counterparts. Information collected in this study may help doctors to find molecular markers and environmental risk factors in gastric cancer unique to Hispanics relative to non-Hispanics in South Texas, so as to help future deployment of improved prevention and surveillance modalities.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT04600466.
Locations matching your search criteria
United States
Texas
San Antonio
Cancer Therapy and Research Center at The UT Health Science Center at San AntonioStatus: Temporarily closed to accrual
Contact: Mio Kitano
Phone: 210-567-6055
PRIMARY OBJECTIVES:
I. To identify molecular differences in gastric adenocarcinoma (GAC) between non-Hispanics and Hispanics.
II. To identify molecular differences between normal, pre-malignant, and malignant gastric samples.
III. To identify environmental and clinicopathological factors in Hispanics associated with specific molecular changes.
SECONDARY OBJECTIVE:
I. To identify molecular differences between the age groups.
OUTLINE:
PART I: Patients' previously collected tissues are obtained for molecular analysis via immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH). Patients undergo collection of saliva for germline testing.
PART II: Patients complete a survey and questionnaires. Patients' previously collected tissues are tested for human papillomavirus (HPV) and Epstein-Barr virus (EBV). Patients' medical records are reviewed.
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationCancer Therapy and Research Center at The UT Health Science Center at San Antonio
Principal InvestigatorMio Kitano