Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients with Breast Cancer

Inclusion Criteria

• Provide signed and dated informed consent form
• Be conscious, willing and able to comply with all study procedures and be available for the duration of the study
• At least 21 years old
• Be scheduled for a breast biopsy (Breast Imaging Reporting and Data System [BIRAD] 4C or 5)
• Patient with an at least 1 cm mass located at < 3 cm depth, approachable by 2.5 inch needle
• Be medically stable as determined by the investigator
• If a female of child-bearing potential, must have a negative urine pregnancy test within 24 hours prior to administration of Definity

Exclusion Criteria

• Females who are pregnant or nursing
• Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable. For example: * Patients on life support or in a critical care unit * Patients with unstable occlusive disease (e.g., crescendo angina) * Patients with clinically unstable cardiac arrhythmias, such as recurrent ventricular tachycardia * Patients with uncontrolled congestive heart failure (New York Heart Association [NYHA] class IV) * Patients with recent cerebral hemorrhage * Patients who have undergone surgery within 24 hours prior to the study sonographic examination
• Patients with known hypersensitivity or allergy to any component of Definity
• Patients with unstable cardiopulmonary conditions or respiratory distress syndrome
• Patients with uncontrollable emphysema, pulmonary vasculitis, pulmonary hypertension or a history of pulmonary emboli