Exercise Intervention for the Prevention of Obesity and Improvement of Movement in Stage 0-III Breast Cancer Survivors

Inclusion Criteria

• Women diagnosed with breast cancer (all stages excluding stage IV)
• Over the age of 18 years; children under the age of 18 will be excluded due to rarity of disease
• The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately. Patients must undergo a pregnancy test via urine strip that will be covered and provided by the principal investigator (PI). Urine strips will be utilized over bloodwork for cost effectiveness. Urine tests will be distributed once before dual-energy X-ray absorptiometry (DEXA) scans
• To volunteer for adipose biopsy patients must be centrally obese with the following criteria (determined by study team at eligibility screening): body mass index (BMI) > 30 kg/m^2 (calculated using height and weight; an upper limit BMI will not be set; we will rely on obtaining physicians’ clearance to assess full eligibility) or body fat > 30% (estimated by bioelectrical impedance), and waist circumference >35 in.; all other participants will not need to be centrally obese, and must have a BMI > 25 kg/m^2
• Speak English
• Is in breast cancer remission with no detectable disease present
• Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity)
• Free from history of chronic disease including uncontrolled diabetes, hypertension or thyroid disease
• Have not experienced a weight reduction >= 10% within the past 6 months
• Currently participate in less than or equal to 60 minutes of structured moderate or vigorous exercise/week
• No planned reconstructive surgery with flap repair during trial and follow-up period
• May use adjuvant endocrine therapy, trastuzumab or pertuzumab if use will be continued for duration of study intervention
• Does not smoke (no smoking during previous 12 months)
• Willing to travel to Dana-Farber Cancer Institute
• Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria

• Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension or thyroid disease
• Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy
• Patients with other active malignancies are ineligible for this study
• Patients with metastatic disease
• Is currently or will be scheduled for surgery, chemotherapy, or radiation treatment associated with their diagnosis
• Has not completed surgery, chemotherapy, or radiation treatment associated with their diagnosis
• History of any musculoskeletal, cardiorespiratory or neurological diseases that preclude the participation in exercise
• Currently participates in more than 60 minutes of structured moderate or vigorous exercise/week
• Is planning reconstructive surgery with flap repair during trial and follow-up period
• Currently smokes
• Is unable to travel to the exercise facilities
• Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study