Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients with Non-small Cell Lung Cancer with Pleural Disease

Inclusion Criteria

• Histologically confirmed non-small cell lung cancer (NSCLC) with pleural disease and PDL1 expression < 50%. Or histologically confirmed diagnosis of malignant pleural mesothelioma not candidates for macroscopic complete resection.
• Adequate blood tests 14 days prior to intraoperative PDT and with values within the ranges specified below:
• Hemoglobin >= 9.0 g/L
• Absolute neutrophil count >= 1.5 x 10^9/L
• Platelets >=100 x 10^9/L
• Total bilirubin =<1.5 x upper limit of normal (ULN) (except participants with Gilbert's Syndrome, who are eligible with bilirubin =< 2.5 ULN)
• Alanine transaminase =<2.5 x upper limit of normal (ULN), unless liver metastases or invasion are present, in which case it must be =<5 x ULN
• Aspartate aminotransferase =<2.5 x ULN, unless liver metastases or invasion are present, in which case it must be =< 5 x ULN
• The patient is on standard of care immunotherapy or combination of chemotherapy & immunotherapy with no evidence of progression or a candidate for chemoimmunotherapy as determined by the treating medical oncologist. Eligible patients that are currently on standard of care treatment will have the systemic therapy paused for 4-6 weeks prior to the surgery and intraoperative PDT and will resume within 4-12 weeks after surgery following standard of care timeframe utilized for restarting systemic therapy after major surgical procedures to ensure adequate post-op recovery and tissue healing
• Male or female patients age >= 18 years old
• Subjects must have an Eastern Cooperative Oncology Group (ECOG) score of 0 – 1
• Life expectancy of at least 12 weeks
• Subjects of child-bearing potential must agree to use adequate contraceptive methods (e.g., hormonal or barrier method of birth control; abstinence) prior to study entry and for 6 months after surgery. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
• The subject must understand the investigational nature of this study and sign an Independent Ethics Committee/Institutional Review Board approved written informed consent prior to receiving any study related procedure

Exclusion Criteria

• Patients who received chemotherapy, chemoimmunotherapy, or radiotherapy within < 4 weeks (6 weeks for nitrosoureas or mitomycin C) or those who have not recovered from reversible adverse events prior to the scheduled surgery and intraoperative PDT
• Patients with untreated or symptomatically unstable treated brain metastases should be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events. Patients with treated and stable brain metastases (at least 28 days from last radiotherapy treatment) are eligible as long as steroids are not required for symptom management
• Patients with porphyria, or with known hypersensitivity to porphyrins or porphyrin-like compounds
• Absolute neutrophil count < 1500
• Platelet count < 100,000
• Left ventricular ejection fraction (LVEF) < lower level of normal (LLN)
• Total bilirubin > 2 mg/dL
• Creatinine clearance < 60 mL/min (Cockcroft Gault equation)
• Alkaline phosphatase (hepatic) > 3 times the upper normal limit
• Serum glutamic-oxaloacetic transaminase (SGOT) or serum glutamate pyruvate transaminase (SGPT) > 3 times the upper normal limit
• NOTE: Roswell Park clinical lab blood chemistry is performed on plasma unless otherwise indicated
• Active or prior documented autoimmune or inflammatory disorders (including inflammatory bowel disease [e.g. colitis or Crohn's disease], systemic lupus erythematosus, Sarcoidosis syndrome, or Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid arthritis, hypophysitis, uveitis, etc.]). The following are exceptions to this criterion: *Patients with vitiligo or alopecia *Patients with hypothyroidism (e.g. following Hashimoto syndrome) stable on hormone replacement *Any chronic skin condition that does not require systemic therapy *Patients without active disease in the last 5 years may be included *Patients with celiac disease controlled by diet alone
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Pregnant or nursing female subjects
• Unwilling or unable to follow protocol requirements
• Any condition which in the Investigator’s opinion deems the subject an unsuitable candidate to receive porfimer sodium
• Received an investigational agent within 30 days prior to enrollment
• Hepatitis B, hepatitis C or human immunodeficiency virus (HIV). Exceptions include past or resolved Hepatitis B (defined as the presence of hepatitis B core antibody [anti- HBc] and absence of HBsAg) and patients positive for hepatitis C (HCV) antibody if polymerase chain reaction is negative for HCV RNA. HIV testing is not required in absence of clinical suspicion of HIV
• History of, or active autoimmune disorder, requiring systemic steroids or immunosuppressive agents. Exceptions allowed: patients with autoimmune dermatologic conditions not requiring systemic steroids or immunosuppressive agents (e.g. vitiligo, eczema, etc.), endocrine-related autoimmune conditions receiving appropriate hormonal supplementation. Use of immunosuppressant drugs such as steroids, azathioprine, tacrolimus, cyclosporine, etc. is not permitted within 4 weeks before recruitment (exception allowed is use of steroids as hormone replacement therapy or as supportive medication e.g. anti-emesis, contrast allergy, pre-medication, etc. or other short-course therapy less than 2 weeks continuously within 4 weeks of study treatment)
• SPECIAL POPULATIONS: Cognitively impaired adults/adults with impaired decision-making capacity
• SPECIAL POPULATIONS: Individuals who are not yet adults (infants, children, teenagers)
• SPECIAL POPULATIONS: Prisoners
• SPECIAL POPULATIONS: Pregnant women