This study examines changes in lung function following radiation treatment. When radiation treatment is used to destroy cancerous cells, it can also damage or destroy healthy, cancer-free cells. This study uses diagnostic scans to create images of patients’ lungs before and after receiving radiotherapy. By comparing images obtained after the treatment with images obtained before the treatment began, doctors may learn more about how radiation affects the lungs and if there are changes in how well air and blood flow through the lungs after radiation treatment.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT02745548.
PRIMARY OBJECTIVES:
I. To determine the association between radiation-induced collapse of branching serial structures (BSS) elements and localized change in pulmonary function.
II. To determine the radiosensitivity of peripheral BSS segments in terms of dose dependent probability of collapse.
SECONDARY OBJECTIVE:
I. To create intensity modulated radiotherapy treatment plans that incorporate radiation dose thresholds for BSS elements while achieving other clinical objectives (prescription dose to planning target volume, dose limits to other organs at risk).
OUTLINE:
Patients undergo radiation therapy per standard of care. Patients also undergo single photon emission tomography (SPECT) and computed tomography (CT) once before radiation treatment and 8-12 month after completing radiation treatment.
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationUniversity of Maryland/Greenebaum Cancer Center
Principal InvestigatorAmit Sawant
