Whole-Body MRI for the Detection and Assessment of Therapy Response in Multiple Myeloma

Inclusion Criteria

• Patients with pathologically confirmed myeloma
• For cross-sectional study, no additional required treatment schedule. For longitudinal study: Patients scheduled to undergo bone marrow biopsy (BMB) and induction therapy (or have gone through 1-2 cycles of induction therapy), followed by either bone marrow transplantation (BMT) or consolidation therapy
• Age >= 18 years
• Eastern Cooperative Oncology Group (ECOG) status 0, 1 and 2
• Women of child-bearing potential must agree to undergo a urine pregnancy screening per standard Radiology departmental protocol in place, to prevent imaging of pregnant patients * A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: ** Has not undergone a hysterectomy or bilateral oophorectomy; or ** Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)
• Ability to understand and the willingness to sign a written informed consent

Exclusion Criteria

• Subjects may not be receiving any other investigational agents for the treatment of the cancer under study for longitudinal study. Patients enrolled for the cross-sectional study may receive other investigational agents
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that, in the opinion of the investigator, would limit compliance with study requirements
• Subjects must not be pregnant or nursing; since pregnancy is a contraindication to administration of gadolinium-based contrast agents. Furthermore, there is a potential for congenital abnormalities and the potential to harm nursing infants, associated with FDG-PET
• Any contraindication to MRI per radiology department’s routine protocol, e.g. MRI-incompatible objects, including but not limited to medical devices (e.g. pacemakers, automatic implantable cardioverter defibrillator [AICD], etc.) and other foreign bodies
• Known severe allergic reaction to gadolinium-based contrast agents
• Patients with uncontrollable claustrophobia, severe lower back pain, and uncontrollable tremors, to the point that it would render them unable to tolerate an MRI study