This early phase I trial studies the use of normal saline with or without heparin in maintaining free flow in peripherally inserted central catheter lines and prevent clogging through these central lines in cancer patients. The information gained from this study may help researchers develop safer ways to maintain the flow of fluids in central lines.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT05029596.
PRIMARY OBJECTIVE:
I. To determine whether or not flushing peripherally inserted central catheter (PICC) lines with normal saline only will maintain patency of lumens.
SECONDARY OBJECTIVE:
I. Determine whether or not removing heparin flushes from PICC line maintenance decreases the risk for central line associated infections.
OUTLINE: Patients are randomized to 1 of 2 groups.
GROUP I: Patients receive heparin and normal saline intravenously (IV) every 8 hours for 7 days per standard of care.
GROUP II: Patients receive normal saline IV every 12 hours for 7 days.
Lead OrganizationUT Southwestern/Simmons Cancer Center-Dallas
Principal InvestigatorMeredith Allen