Laser Interstitial Thermal Therapy and Hypofractionated Radiation Therapy for the Treatment of Newly Diagnosed High-Grade Gliomas

Inclusion Criteria

• Patients with radiographic evidence of suggestive of a primary high-grade glioma
• Brain magnetic resonance imaging (MRI) with contrast demonstrates an enhancing mass within 60 days prior to registration. Patient must be deemed a candidate for LITT from MRI by neurosurgery in order to be eligible
• History and physical including neurological exam within 30 days prior to registration
• Karnofsky performance status >= 50% within 30 days prior to registration
• Age >= 18 years old
• Patients must have signed an approved informed consent
• Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion
• Female patients of child-bearing potential must have a negative pregnancy test within 7 days prior to study registration

Exclusion Criteria

• Patients that are not surgical candidates for stereotactic biopsy or laser ablation
• Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following: * History or presence of serious uncontrolled ventricular or significant arrhythmias. * Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism
• Infratentorial tumor or evidence of leptomeningeal spread
• Inability to undergo a MRI
• Pregnant or breast-feeding women