Increasing Cervical Cancer Screening Uptake Among Emergency Department Patients

Cervical cancer (CC) is preventable. Screening for CC aims to identify treatable lesions

prior to the development of invasive CC which, without screening, is often first detected

at a stage when comfort care is all that can be offered. Still, only 80% of U.S. women

age 21 - 65 report adherence to U.S. Preventive Services Task Force (USPSTF) CC screening

recommendations. This rate is considerably below the Healthy People 2020 target of 93%8.

Lower rates of screening have been particularly pronounced among racial and ethnic

minorities and patients with lower education levels. The group most likely to be

non-adherent with screening guidelines is women who use the emergency department (ED) for

their usual source of care. The ED setting, therefore, is optimal for the deployment of

an intervention to promote CC screening. Although designed to address acute illnesses and

injuries, the ED is an effective environment to advance preventive health. Numerous

preventive health interventions have been successfully deployed in the ED including

smoking cessation, HIV testing, and depression screening. Interventions delivered in the

ED often suffer from lack of follow up and hence low adherence. Novel approaches are

needed to reinforce health messages delivered in the acute context of the ED. Short

Message Service (SMS) on mobile phones, also known as text messaging, is a low-cost,

scalable, and effective means of delivering health behavior interventions. According to

the Pew Research Center, the vast majority of Americans - 95% - own a cell phone, and an

estimated 98% of all cell phones have texting capabilities. Evidence-based SMS

interventions for health behavior include smoking cessation,primary care attendance,

breast cancer screening, and sun safety, among others. However, minimal research has been

conducted applying SMS interventions to CC screening and no prior research, apart from

our pilot work, has targeted a CC prevention intervention by leveraging the universal

healthcare access setting of the ED. In 2018-19 the investigators conducted a randomized

clinical trial pilot (ClinicalTrials.gov #NCT03483610; NIH Grant ID: UL1TR002001) among

ED patients non-adherent with USPSTF recommendations comparing an SMS intervention group

to a referral-only control group to improve CC screening uptake at follow-up. The

intervention consisted of a series of text messages, grounded in behavioral change

theory, aimed at generating intention to get screened. The results of this pilot: (A)

demonstrated the feasibility of our approach, (B) showed preliminary evidence of

efficacy, and (C) provided an effect size estimate. Our overarching goal is to develop a

low-cost, scalable SMS intervention that increases CC screening uptake among ED patients

and can be deployed in heterogenous ED settings. The proposed randomized controlled trial

will test the efficacy of this intervention. Step 1 of our approach is to identify

whether the participant is adherent with screening guidelines. Step 2 is to randomize

non-adherent participants to one of the two treatment conditions: (1) referral only

(control) or, (2) referral and an SMS-intervention consisting of a series of text

messages, grounded in behavioral change theory, aimed at generating intention and

autonomous motivation to get screened. To limit costs and increase the scalability of the

intervention, determination of adherence with screening guidelines via a

self-administered questionnaire on a tablet computer will be evaluated. A total of 1,460

non-adherent women, age 21-65, will be recruited from a high-volume urban ED and a

low-volume rural ED, randomized among study conditions, and followed-up at 150 days to

assess interval CC screening uptake.

Aim 1: Compare CC screening uptake between SMS intervention and control groups.

Hypothesis 1: Uptake of CC screening in the SMS intervention group will be greater than

in the control group at 150-day follow-up.This aim will determine the efficacy of the

intervention.

Aim 2: Compare the impact of in-person (using research staff) versus self-administered

(using a tablet) determination of CC screening adherence on the efficacy of the

intervention.

Hypothesis 2: The method of determining adherence will not impact the efficacy of the

intervention. This aim will evaluate an approach to limit cost and increase the

scalability of intervention implementation. Aim 3: Identify mediators and explore

moderators of intervention effects on CC screening uptake at follow-up.

Hypothesis 3: Uptake in the intervention group will be mediated by theory-posited

proximal predictors. This aim will elucidate the mechanism of behavioral change resulting

from the intervention and identify differential effects among study sub-groups.

This project leverages the universal access setting of the ED to target women most at

risk for non-adherence with CC screening guidelines. A low-cost, scalable intervention

that increases CC screening uptake in this population would decrease CC incidence and

save lives. Our next step would be a multi-site effectiveness trial using the NCI

Community Oncology Research Program (NCORP) Network.