Donor Gamma Delta T-Cell Infusion for the Treatment of Acute Myeloid Leukemia in Patients at High Risk of Relapse after Allogeneic Hematopoietic Stem Cell Transplant

Inclusion Criteria

• Male or female, aged between 18 and 75 years of age undergoing alloHCT for the treatment of European LeukemiaNet (ELN) 2022 adverse risk AML
• Have < 5% blasts in bone marrow by morphology at the time of transplantation. Patients with pre-alloHCT or post-alloHCT flow cytopemtric or molecular evidence of MRD are allowed
• To minimize the risk of mortality or complications that are unrelated to the study, the patients are also required to have a Karnofsky performance status (KPS) >= 70% during the study screening
• They are to be free of symptomatic congestive heart failure or uncontrolled arrhythmia
• Have adequate organ function (total bilirubin =< 2 mg/dL except for patients with Gilbert syndrome or hemolysis, and alanine aminotransferase [ALT] and aspartate aminotransferase [AST] < 3 times of the upper limit of normal; have estimated creatinine clearance > 40 mL/min)
• Negative serum pregnancy test
• Note: Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for at least 30 days following study treatment (T-cell infusion); should a woman subject or female partner of a male subject become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately
• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Agreement to adhere to Lifestyle Considerations throughout study duration

Exclusion Criteria

• Current use of concomitant systemic glucocorticoid at the time of gamma delta T-cell infusion for any reason will not be allowed in order to avoid their immunosuppressive effects on gamma delta T-cell function
• Active grade II-IV acute GVHD (patients with prior GVHD should be off prednisone for at least 14 days prior to infusion of the study cell product)
• Uncontrolled serious infection
• Morphologic relapse of leukemia at any timepoint after HCT
• Active central nervous system malignancy
• Pregnancy or lactation
• Treatment with another investigational drug or other intervention within 14 days of T-cell infusion