This study investigates the usefulness of performing treatment simulation scans using magnetic resonance imaging (MRI) in different positions for patients with cancer undergoing spinal stereotactic body radiation therapy (SBRT). An MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. Treatment simulation is a process used to plan radiation therapy so that the target area is precisely located and marked. This study may help doctors learn the best practice for spinal SBRT planning and dose delivery.
Additional locations may be listed on ClinicalTrials.gov for NCT05155423.
Locations matching your search criteria
United States
Texas
Houston
M D Anderson Cancer CenterStatus: Temporarily closed to accrual
Contact: Amol J. Ghia
Phone: 713-792-4928
PRIMARY OBJECTIVES:
I. Assess the feasibility of performing MRI scans in the treatment position for accurate treatment planning and dose delivery in spinal stereotactic body radiation therapy (spinal SBRT).
II. Characterize the improved accuracy of image fusion between MRI and computed tomography (CT) and its dosimetric impact when performing MRI scans in treatment position in spinal SBRT.
III. Assess the ability of MRI simulation to accurately target extended spinal targets beyond the current targeting limitations (> 3 consecutive vertebral body levels).
IV. Optimize the workflow of using MRI simulation in treatment planning and dose delivery.
OUTLINE:
STAGE I: Patients are assigned to 1 of 2 groups.
GROUP 1: Patients undergo treatment simulation via an MRI scan with mask immobilization and an MRI scan without immobilization. Patients then undergo standard of care CT-guided SBRT.
GROUP 2: Patients undergo treatment simulation via an MRI scan with Elekta BodyFix (plastic wrap) immobilization and an MRI scan without immobilization. Patients then undergo standard of care CT-guided SBRT.
STAGE II: Patients are assigned to 1 of 2 groups.
GROUP 1: Patients undergo treatment simulation via an MRI scan with mask immobilization. Patients then undergo MRI-guided SBRT (MRI/linear accelerator [Linac]).
GROUP 2: Patients undergo treatment simulation via an MRI scan with Elekta BodyFix (plastic wrap) immobilization. Patients then undergo MRI-guided SBRT (MRI/Linac).
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationM D Anderson Cancer Center
Principal InvestigatorAmol J. Ghia
