Genetic Counseling Patient Preference Intervention versus Conventional Genetic Counseling for Women at Elevated Risk for Breast Cancer

This early stage I trial compares a genetic counseling patient preference intervention to conventional genetic counseling for women at elevated risk for breast cancer. Women at elevated breast cancer risk may be offered genetic counseling and genetic testing to further define whether they are at high risk (e.g. hereditary risk; BRCA mutation positive); moderate risk (e.g. risk based largely on family history and/or polygenic risk score) or average risk (e.g. general population). Genetic counseling may improve basic genetic knowledge, produce more accurate risk perceptions and tailor recommendations for greater perceived personal control regarding breast cancer risk. This trial may help researcher determine if a genetic counseling patient preference intervention can take the place of conventional genetic counseling, while being non-inferior in terms of adherence to screening recommendations, breast cancer genetic knowledge, accurate perception of risk, breast cancer-specific worry, and satisfaction with counseling compared to conventional genetic counseling.

Additional locations may be listed on ClinicalTrials.gov for NCT05325151.

See trial information on ClinicalTrials.gov for a list of participating sites.

Trial PhaseNo phase specified

Trial Typeprevention

Lead OrganizationOhio State University Comprehensive Cancer Center

Principal InvestigatorKevin Sweet

• Primary IDOSU-22013
• Secondary IDsNCI-2022-01136, 2022C0038
• ClinicalTrials.gov IDNCT05325151