This study evaluates the role of environmental exposures in the development of more aggressive thyroid cancer. Thyroid cancer incidence has been steadily increasing since the 1970’s in the United States and worldwide. Early detection of small, papillary thyroid cancers using high quality diagnostic imaging explains only about 50% of this increase, suggesting that there are changes in the prevalence of environmental risk factors that may be playing a role in this increase. To assess these environmental factors, this study uses dried blood microsampler technology to collect small amounts of blood from thyroid cancer patents. This technology is minimally invasive and can be used to collect repeated blood measurements at home, without the need for specialized training. Additional exposure information is collected using questionnaires. Information gathered in this study may help researchers identify the causes of thyroid cancer not explained by more advanced diagnostic imaging, which may lead to prevention.
Additional locations may be listed on ClinicalTrials.gov for NCT05172921.
Locations matching your search criteria
United States
New York
New York
Icahn School of Medicine at Mount SinaiStatus: Active
Contact: Maaike van Gerwen
Phone: 347-603-9090
Mount Sinai Union SquareStatus: Active
Contact: Mohemmed Nazir Khan
Mount Sinai WestStatus: Active
Contact: Raymond Chai
PRIMARY OBJECTIVES:
I. Build a repository of thyroid cancer patients consisting of demographic and clinical data, blood samples, pathology samples, and exposure questionnaire data.
II. Characterize the metabolome in non-familial, papillary thyroid cancer patients and identify difference in exposure profiles based on metabolomics and questionnaire data.
III. Assess how different exposure profiles of non-familial, papillary thyroid cancer patients correlate with clinical outcomes, including disease-specific survival, disease recurrence, and mutational profiles.
IV. Elucidate the mechanism by which environmental exposures contribute to non-familial, papillary thyroid cancer carcinogenesis by using different omics techniques.
OUTLINE: This is an observational study.
Patients complete at-home blood collection on study. Patients also complete questionnaires on study.
Trial PhaseNo phase specified
Trial TypeNot provided by clinicaltrials.gov
Lead OrganizationIcahn School of Medicine at Mount Sinai
Principal InvestigatorMaaike van Gerwen