A Study of Evorpacept (ALX148) With Cetuximab and Pembrolizumab for Refractory Microsatellite Stable Metastatic Colorectal Cancer

Inclusion Criteria

• Inclusion Criteria: To be eligible to participate in this study, an individual must meet all of the following criteria: - Have a diagnosis of metastatic colorectal cancer previously treated with at least two lines of therapy for unresectable/metastatic disease - Have microsatellite stable disease - Adequate hematologic and end organ function Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: - Patients with known MSI-high status or known mismatch repair deficiency (dMMR) - Patients in whom both mismatch repair and microsatellite stability status are unknown - History of severe allergic, anaphylactic, or other hypersensitivity reactions to any of the study medications or their classes - Left-sided (at or distal to the splenic flexure) RAS/BRAF wild-type metastatic colorectal cancer who are EGFR inhibitor naïve. - Prior therapy with an anti-PD-1, anti-PD-L1, anti PD L2, anti-CD47, or anti-SIRPα agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (eg, CTLA-4, OX 40, CD137)