Hypofractionated Intensity-Modulated Radiation Therapy with Chemotherapy and Immunotherapy for the Treatment of Stage III Non-Small Cell Lung Cancer

Inclusion Criteria

• Ability of participant or legally authorized representative (LAR) to understand this study, and participant or LAR willingness to sign a written informed consent
• Males and females age >= 18 years
• Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2
• Measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1
• Women of childbearing potential must have a negative urine or serum pregnancy test within one month prior to being enrolled onto the study
• Pathologically proven diagnosis of stage III non-small cell lung cancer (NSCLC)
• No positron emission tomography(PET)/computed tomography (CT) evidence of metastatic disease
• An magnetic resonance imaging (MRI) of the brain with contrast excluding intracranial metastatic disease (or CT with contrast if MRI is medically contraindicated). An MRI without contrast is only permitted if the subject cannot have contrast for medical reasons
• If a pleural effusion is present, it must be tapped and confirmed to be cytologically negative. If an effusion is deemed too small to safely tap, the subject will be eligible
• Women of child-bearing potential and men with partners of child-bearing potential must agree to practice sexual abstinence or to use the forms of contraception listed in Child-Bearing Potential/Pregnancy section for the duration of study participation and for 90 days following completion of therapy
• Eligible to receive concurrent chemoradiation as judged by radiation oncologist and medical oncologist

Exclusion Criteria

• Current or anticipating use of other anti-neoplastic or investigational agents while participating in this study
• Diagnosed with a psychiatric illness or is in a social situation that would limit compliance with study requirements in the opinion of the Investigator
• Evidence of severe or systemic disease (e.g., unstable or uncompensated respiratory, cardiac, hepatic, or renal disease) that would interfere with study protocol as judged by the investigator
• Is pregnant or breastfeeding
• Active connective tissue disorders, such as active lupus or scleroderma
• Known acquired immune deficiency (human immunodeficiency virus [HIV] positive [+]/AIDS)
• Has a known allergic reaction to any excipient contained in the study drug formulations
• Active grade 3 (per the National Cancer Institute [NCI] Common Terminology Criteria for Adverse Events [CTCAE], version 5.0) or higher viral, bacterial, or fungal infection within 2 weeks prior to the first dose of study treatment
• Patients who have a hiatal hernia in which any volume of the stomach will receive > 45 Gy should be excluded from participation