The purpose of this clinical trial (called the FLOTILLA study) is to give continued
access to the study medicines, as well as safety follow-up, for participants in prior
clinical trials of encorafenib and/or binimetinib.
All participants who took part in earlier encorafenib and/or binimetinib studies may
participate the FLOTILLA study if they are still benefiting from the use of the study
medicines. This will be determined by the study doctor. People may not participate in the
FLOTILLA study if they have not enrolled in a prior study of encorafenib or binimetinib.
Participants that had enrolled but had stopped receiving the study treatment in a prior
study cannot enrolled in this study. Participants in the FLOTILLA study will receive
encorafenib and/or binimetinib at the same dose and frequency as in their prior study,
for up to about 5 years.
Additional locations may be listed on ClinicalTrials.gov for NCT05203172.
Locations matching your search criteria
United States
Georgia
Atlanta
Emory University Hospital MidtownStatus: Active
Contact: Jennifer Wilkinson Carlisle
Phone: 404-778-1900
Emory University Hospital/Winship Cancer InstituteStatus: Active
Name Not Available
This is an open-label, continuation study for participants receiving study
intervention(s) in an encorafenib/binimetinib Parent Study. The study is being conducted
under a Master Protocol for Encorafenib/Binimetinib Continuation Sub-Studies with an
individual encorafenib/binimetinib continuation sub-study protocol for each eligible
Parent Study. Approximately 75 participants from potentially qualifying Parent Studies
will be included in this Encorafenib/Binimetinib Continuation study.
This continuation study includes multiple sub-study protocols to allow participants from
each of the following parent studies: C4211001 - NCT01320085; C4211003 - NCT01849874;
C4221003 - NCT03864042; C4221005 - NCT01543698; C4221006 - NCT03911869; C4221009 -
NCT02928224; C4221010 - NCT01436656; C4221013 - NCT02159066; ANCHOR-CRC - NCT03693170
Lead OrganizationPfizer Inc