Evaluation of Tissue and Blood for Patients Undergoing Surgery, Biopsy or Endoscopy for Gastrointestinal Cancers

OBJECTIVES:

I. To collect and store normal and malignant tissue from patients with gastric cancer, gastrointestinal stromal tumors (GIST), esophageal cancer, pancreatic cancer, hepatocellular cancer, biliary tract cancer, neuroendocrine cancer, peritoneal mesothelioma, anal cancer, colorectal cancer, appendiceal cancer, and small bowel cancer.

II. To collect and store peripheral and portal venous system blood samples from patients with gastric cancer, GIST, esophageal cancer, pancreatic cancer, hepatocellular cancer, biliary tract cancer, neuroendocrine cancer, peritoneal mesothelioma, anal cancer, colorectal cancer, appendiceal cancer, and small bowel cancer .

III. To create a database for the collected tissue and allow access to relevant clinical information for current and future protocols.

IV. To create tissue microarrays for each gastrointestinal cancer subtype, namely, gastric cancer, GIST, esophageal cancer, pancreatic cancer, hepatocellular cancer, biliary tract cancer, neuroendocrine cancer, peritoneal mesothelioma, anal cancer, colorectal cancer, appendiceal cancer, and small bowel cancer- to facilitate future molecular studies.

V. To digitally capture high-resolution images of stained slides cut from banked tissue for identification of morphologic features using computational algorithms, to be correlated with clinical and molecular outcome data and used to find digital biomarkers.

VI. To grant access to Dr. Shergill, and additional clinical study team members to this database (as it is being acquired) of the coupled patient tissue samples (normal and malignant) and relevant clinical information that may be implicated in the pathogenesis of gastrointestinal (GI) cancers.

OUTLINE: This is an observational study.

Participants undergo blood sample collection and tissue collection from standard of care procedures while on study.