Skip to main content
An official website of the United States government
Government Funding Lapse
Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Testing the Effect of an Anticancer Drug, Onvansertib, in Advanced-Stage Small Cell Lung Cancer

Trial Status: active

This phase II study evaluates the safety and effectiveness of onvansertib for the treatment of patients with small cell lung cancer. Onvansertib is an enzyme inhibitor that disrupts cell replication and induces tumor cell death by binding to a receptor called PLK1, which is crucial for the regulation of cell replication, and plays a key role in tumor cell proliferation.