A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations

Inclusion Criteria

• - INCLUSION CRITERIA: - Participants must have diffuse glioma, WHO grades 2-4, histologically confirmed by Laboratory of Pathology, NCI. - IDH1 or IDH2 mutation status confirmed by TSO500 performed in LP, NCI or prior documentation of IDH1 or IDH2 mutation status - Participants must have received prior treatment (e.g., radiation, conventional chemotherapy) prior to disease progression. - Participants must have recurrent disease, proven histologically or by imaging studies - Participants who have undergone prior surgical resection are eligible for enrollment to cohorts 1-4. - Age >15 years - Karnofsky >70% - Participants must have adequate organ and marrow function as defined below: - leukocytes >=3,000/microliter - absolute neutrophil count (ANC) >=1,500/microliter - platelets >100,000/microliter - total bilirubin <=2x ULN (ULN 1.3 mg/dl) except for participants with Gilbert Syndrome - AST < 3x ULN (ULN 34U/L) - ALT < 3x ULN (ULN 55U/L) - serum creatinine < 1.5 mg/dL - calculated creatinine clearance by CKD-EPI equation > 60 cc/min - Participants must have recovered from the adverse effects of prior therapy to grade 2 or less (per Common Terminology Criteria for Adverse Events (CTCAE) version 5.0) - Individuals of child-bearing potential (IOCBP) and men must agree to use highly effective contraception (hormonal, intrauterine device (IUD), abstinence, tube ligation, partner has had a previous vasectomy) at the study entry, for the duration of study treatment, and up to 3 months after the last dose of zotiraciclib - Breastfeeding participants must be willing to discontinue breastfeeding from study treatment initiation through 3 months after study treatment discontinuation - Participants must be scheduled for brain tumor biopsy or surgical resection at NIH (Cohort 5 only) - The ability of a participant, parent or legal guardian of minor participant to understand and the willingness to sign a written informed consent document. No Legally Authorized Representative can provide initial consent. EXCLUSION CRITERIA: - More than one prior disease relapse (WHO grade 3-4) or more than two prior disease relapses (WHO grade 2) for Phase II only. For Phase I enrollment, there are no limits on the number of prior recurrences. - Prior therapy with: - any investigational agent (including IDH mutant inhibitor) and/or standard of care cytotoxic therapy within 28 days prior to treatment initiation - vincristine within 14 days prior to treatment initiation - nitrosoureas within 42 days prior to treatment initiation - procarbazine within 21 days prior to treatment initiation - non-cytotoxic agents, e.g., interferon, tamoxifen, thalidomide, cis-retinoic acid, within 7 days prior to treatment initiation - surgery within 14 days prior to treatment initiation - radiation therapy within 30 days prior to treatment initiation - bevacizumab for tumor treatment. Note: participants who received bevacizumab for symptom management, including but not limited to cerebral edema, or pseudo progression can be enrolled - Prolonged QTc >470ms as calculated by correction formula on screening electrocardiogram (ECG) (QTCf can be used; QTCb can be used for participants with sinus bradycardia) ) - Prior invasive malignancies within the past 3 years prior to study treatment initiation (with the exception of non-melanoma skin cancers, carcinoma in situ of the cervix, melanoma in situ, or any localized cancer for whom the systemic standard of care therapy is not required) - History of allergic reactions attributed to compounds of similar chemical composition to zotiraciclib, such as flavopiridol - Pregnancy (confirmed with beta-HCG serum or urine pregnancy test performed at screening) - Uncontrolled intercurrent illness or social situations that would limit compliance with study requirements - Uncontrolled primary diabetes mellitus