Scalp Cooling for Chemotherapy-Induced Hair Loss in African American Patients with Stage I-III Breast or Non-small Cell Lung Cancer

PRIMARY OBJECTIVE:

I. To assess the efficacy of scalp cooling devices in preventing chemotherapy-induced alopecia in persons of color with hair types 3 or 4 using hair products and hair styles that will enhance contact between the scalp and cooling device.

SECONDARY OBJECTIVE:

I. To investigate whether scalp cooling can decrease the risk of persistent chemotherapy alopecia in skin of color (SOC) patients and impact patient quality of life.

EXPLORATORY OBJECTIVES:

I. To define molecular mechanisms implicated in chemotherapy-induced alopecia (CIA), persistent chemotherapy-induced alopecia (PCIA), and scalp cooling (SC) effect.

II. Identify predictive markers for cooling success through transcriptome profiling on hair follicles before and after chemotherapy in intervention and control groups.

OUTLINE: Patients are self-assigned or randomly assigned to 1 of 3 groups.

GROUP I (SC WITH HAIRSTYLE): Patients undergo scalp cooling with hairstyle (braids, twists, cornrows) before, during, and after chemotherapy infusion on study.

GROUP II (SC WITH CONDITIONER AND WATER): Patients undergo scalp cooling after coating hair with conditioner and water emulsion before, during, and after chemotherapy infusion on study.

GROUP III (CONTROL, NO SCALP COOLING): Patients receive standard of care treatment without any prevention for chemotherapy-induced alopecia.