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Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations
Trial Status: active
This study evaluates individuals known or suspected to have pancreatic cancer to build a large database of information dedicated to minimizing disparities and personalizing care for affected individuals. This database is a valuable resource that involves collection, processing, and storage of blood, other bodily fluids, and tissue (obtained during biopsy or surgery) to improve understanding of health and disease. When combined with information and medical images obtained through routine care, this study will be able to investigate biological processes such as the role of obesity in promoting the development and progression of pancreatic cancer in various racial groups.
Inclusion Criteria
Adults (of any gender) 18 years of age or older at time of signing informed consent
Patients who self-report as AA or NHW, and present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating FPC site or UMMC with a clinical suspicion or diagnosis of a pancreatic tumor will be eligible. For tissue obtained through routine diagnostic procedures, confirmation is made by the institutional pathologist
Exclusion Criteria
Patient is under 18 years of age
No suspicion or diagnosis of a pancreatic cancer or tumor
Self-reported race/ethnicity other than NHW, AA
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT05687188.
I. To evaluate the molecular and radiologic landscape of pancreatic ductal adenocarcinoma (PDAC) tumors from African-American (AA) and non-White Hispanic (NHW) cases (matched on age at diagnosis, gender, histology, and stage).
II. To compare biological properties of adipose tissue (AT) dysfunction between AA and NHW PDAC cases.
III. To assess the role of AT-PDAC interactions in influencing tumor growth, metastasis, and therapeutic response.
OUTLINE: This is an observational study.
Patients complete a questionnaire on study, undergo collection of blood and tumor tissue samples at the time of standard of care (SOC) procedures on study, undergo collection of SOC medical images on study, and have their medical records reviewed on study. Patients may also undergo collection of other bodily fluids such as but not limited to saliva, hair, urine, stool, and cystic fluid on study.
