Comparing Octreotide with Perioperative Antibiotics versus Prolonged Antibiotics in Patients Undergoing a Whipple Procedure

This phase II/III trial compares the effect octreotide and the duration of antibiotic treatment has on outcomes in patients undergoing a Whipple procedure. A Whipple procedure is a surgery that may remove all or part of the pancreas, part of the intestines, stomach and gallbladder. Leakage from the pancreas due to damaged pancreatic ducts (fistula) is a major complication following pancreatic resection often delaying further treatment and increasing hospital stays. Antibiotics along with octreotide, which works by inhibiting pancreatic secretions, is standard treatment for a pancreatic fistula. This study will determine if the length of antibiotic treatment decreases the rate of fistulas and shortens hospital stays.

Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT04329039.

Trial PhasePhase II/III

Trial Typetreatment

Lead OrganizationMayo Clinic in Rochester

Principal InvestigatorMichael L. Kendrick

• Primary ID18-010128
• Secondary IDsNCI-2022-11062
• ClinicalTrials.gov IDNCT04329039