Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Inclusion Criteria

• Inclusion Criteria: Dose Escalation: - Patients with advanced (metastatic or unresectable) KRAS G12C mutant solid tumors who have received standard of care therapy or are ineligible to receive such therapy. Phase II: - Patients with advanced (metastatic or unresectable) KRAS G12C mutant non-small cell lung cancer who have received platinum-based chemotherapy regimen and immune checkpoint inhibitor therapy, unless patient was ineligible to receive such therapy - Patients with advanced (metastatic or unresectable) KRAS G12C mutant colorectal cancer who have received fluropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, unless patient was ineligible to such therapy. All patients: - ECOG performance status of 0 or 1. - Patients must have a site of disease amenable to biopsy and be a candidate for tumor biopsy according to the treating institution's guidelines. Exclusion Criteria: - Tumors harboring driver mutations that have approved targeted therapies, with the exception of KRAS G12C mutations - Prior treatment with a KRAS G12C inhibitor is excluded for patients in a subset of groups in Phase II. - Active brain metastases, including symptomatic brain metastases or known leptomeningeal disease - Clinically significant cardiac disease or risk factors at screening - Insufficient bone marrow, hepatic or renal function at screening Other protocol-defined inclusion/exclusion criteria may apply