Red Blood Cell Transfusion Thresholds for Improved Quality of Life for Patients Undergoing a Pancreatectomy for Pancreatic Cancer

Inclusion Criteria

• Male or female >= 18 years of age at Visit 1
• Documentation of a pancreatic cancer diagnosis as evidenced by one or more clinical features meeting the following criteria: * CT evidence of a mass in the pancreas consistent with cancer * Tissue diagnosis of cancer either before surgery or from the resected specimen * Preoperative evaluation suggestive that pancreatic resection is feasible
• Written informed consent (and assent when applicable) obtained from subject or subject’s legal representative and ability for subject to comply with the requirements of the study

Exclusion Criteria

• Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study
• Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data
• Patients who are unable to receive or who refuse blood products
• Patients involved in an autologous pre-donation program
• Patients found to have metastatic disease upon entry into abdomen-having been randomized, these patients will be removed from the study and replaced with another patient
• Patients found to not have cancer during the operation- If the resected lesion proves not to be cancer, the patient will remain as an enrolled patient but not evaluable and replaced by another patient
• Established severe cardiovascular disease with estimated 5-year survival <10% based on Framingham risk score
• Unstable angina or recent myocardial infarction (MI)/stroke within 6 months