Evaluating the Effect of 2D Antiscatter Grids on the Quality of CBCT Images Obtained from Patients with Prostate, Head and Neck, and Upper Abdomen Cancers

Inclusion Criteria

• Provision to sign and date the consent form
• Stated willingness to comply with all study procedures and be available for the duration of the study
• Be a male or female aged 18–100
• Participants who will be treated or are currently being treated with CBCT-guided photon therapy for prostate or prostate-bed, abdomen, head and neck, or pelvic cancers, or with image-guided proton therapy for prostate or prostate bed cancer

Exclusion Criteria

• Metallic implants in the CBCT scan volume, such as hip prostheses or spine stabilization hardware. Patients with pacemakers, defibrillators, or other implanted electronic devices. Dental implants, filings, or fiducial markers may be acceptable, and the decision for inclusion/exclusion will be on a case-by-case basis, by reviewing prior computed tomography (CT) images of the study candidate. Patient’s prior CT images will be reviewed by the principal investigator (PI) or the site PI
• Patients who do not have the ability to lie still for the duration of his/her CBCT imaging and treatment should be excluded. If image artifacts in prior scans are deemed excessive, patient will be excluded from the study
• Known pregnancy. (Per standard of care [SOC], a pregnancy test will be performed prior to CBCT scan on day 1. At this time, women of child-bearing potential (WOCBP) will receive a pregnancy test to re-confirm eligibility). * Women of child-bearing potential are described as: ** Age 55 or younger thatwho have not had a negative pregnancy test within 3 days. This excludes patients who have had tubal ligation or are already post-menopausal