TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients, THRIVE-65 Study

Inclusion Criteria

• Women age >= 65
• Diagnosed with stage I-III invasive breast cancer
• Body mass index (BMI) between 18-50 kg/m^2
• Scheduled to begin at least 10 weeks of neoadjuvant or adjuvant cytotoxic chemotherapy (+/- human epidermal growth factor receptor 2 [HER-2] directed therapy or immunotherapy) for curative intent. Must be randomized before start of second cycle
• Patients receiving neo/adjuvant cytotoxic chemotherapy as part of a clinical trial are generally eligible. If the trial alters the chemotherapy agents/doses according to patient response (e.g.; I-SPY trials), patients are only considered eligible if there is a standard treatment regimen of at least 10 weeks that is delivered to all patients, regardless of response. In such a trial, only the standard part of the treatment regimen will be considered in RDI calculations
• Self-reported ability to walk for 6 minutes and/or 2 blocks (with or without assistive device)
• Ability to provide written informed consent
• Ability to understand, speak, and read English. This is because many of the study instruments used are not readily available in multiple languages. Additionally, site-based study staff, such as exercise physiologists, are not bilingual and not all sites have access to interpreters

Exclusion Criteria

• Following a therapeutic diet for co-morbid disease where the THRIVE-65 diet would be contraindicated as assessed by the registered dietician (RD)
• Engaging in 2 or more sessions of strength training exercise per week over a period of at least 3 consecutive months over the past year
• Engaging in aerobic activity at a level that includes competitive events (e.g., marathon, triathlon, running races) over the past year
• Presence of medical conditions or medications that would prohibit participation in an exercise program
• Current use of weight-loss medication
• Documented history of alcohol or substance abuse within the past 12 months
• History of dementia