Hyperpolarized 13C-Pyruvate Metabolic Magnetic Resonance Imaging for the Diagnosis and Risk-Stratification of Prostate Cancer
This phase I trial tests the safety and effectiveness of an imaging scan called hyperpolarized 13C-pyruvate metabolic magnetic resonance imaging (MRI) in patients who are suspected or known to have prostate cancer. MRI is a procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. Metabolic MRI is a specialized type of MRI that uses a compound called hyperpolarized (HP)13 carbon (C)-pyruvate that when given by injection is taken up by tumor cells. In addition to imaging the prostate, as a standard MRI does, HP 13C MRI can also show areas of abnormal metabolism within the prostate. Prostate cancer cells have a metabolism that is different from normal cells and this agent can help to detect and visualize these tumor cells. Adding hyperpolarized 13C-pyruvate MRI may help researchers understand if metabolic MRI can improve the ability to diagnose and identify risk factors in prostate cancer.