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Intermittent Fasting Using a Fasting-Mimicking Diet to Improve Prostate Cancer Control and Metabolic Outcomes

Trial Status: active

This phase II trial tests how well intermittent fasting using a fasting-mimicking diet works in improving response to cancer treatment in patients with castration sensitive prostate cancer that has spread from where it first started (primary site) to other places in the body (metastatic). The fasting mimicking diet is a 5-day program of plant-based products that are consumed and puts the body into a fasting state. Examples of these food products include: soups, broths, energy bars, energy drinks, cracker snacks, herbal teas, and supplements. A fasting diet can positively change the way the body responds to cancer treatment. Many cancer treatments can negatively impact the body's heart and metabolic health, including loss of lean muscle mass, gain of fat mass, insulin resistance and altered fat metabolism. In contrast, fasting diets have shown health benefits including improved insulin sensitivity, and heart health. Consuming a fasting-mimicking diet may increase energy levels and improve quality of life, mood, sleep, and long-term survival in patients with metastatic castration sensitive prostate cancer.