This clinical trial tests how well a remotely delivered yoga intervention works in improving symptoms and quality of life of patients on active therapy for multiple myeloma. Yoga includes a diverse group of mind-body practices which involve physical postures, breathing exercises, and meditation practices. Yoga-based interventions in multiple studies have shown improvement in quality of life, physical symptoms, such as fatigue and sleep, and psychological outcomes, such as anxiety and depression. As symptom and treatment burden increases in multiple myeloma patients, there is an increased need for integrated non-drug interventions to improve symptoms and quality of life.
Study sponsor and potential other locations can be found on ClinicalTrials.gov for NCT06061302.
PRIMARY OBJECTIVES:
I. Evaluate the feasibility of implementing a weekly 40-minute remote yoga intervention in patients with multiple myeloma on active treatment for 12 weeks by measuring accrual, compliance, and overall completion rate of the program.
II. Evaluate the short-term impact of weekly remote yoga intervention in patients with multiple myeloma on active treatment including physical symptoms (pain, fatigue, sleep) and psychological symptoms (anxiety, depression) by measuring Edmonton Symptom Assessment System (ESAS-r) after each session weekly.
III. Evaluate the impact of a weekly 12-week remote yoga intervention program in patients with multiple myeloma on active treatment on health-related quality of life (HRQOL) over time by measuring HRQOL questionnaire (European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 [EORTC QLQ-C30]) responses at baseline, 6 weeks, and 12 weeks.
IV. Evaluate the impact of a 12-week remote yoga intervention program in patients with multiple myeloma on active treatment by measuring total activity (measured by daily steps) and heart rate utilizing remote sensor data from either Apple Watch or Fitbit.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients attend a 40 minute remotely guided mindful yoga intervention once a week for 12 weeks and may wear an activity tracker on study.
ARM II: Patients complete their usual activities for 12 weeks and then attend a 40 minute remotely guided mindful yoga intervention once a week for 12 weeks and may wear an activity tracker on study.
Trial PhaseNo phase specified
Trial Typesupportive care
Lead OrganizationBanner University Medical Center - Tucson
Principal InvestigatorShaunak Pandya
