Adagrasib in Combination with Olaparib for the Treatment of KRAS G12C Mutated Advanced Solid Tumors with a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers

Inclusion Criteria

• Patients must be >= 18 years old
• DOSE ESCALATION COHORT: Histologically confirmed diagnosis of a solid tumor malignancy with a KRAS G12C mutation. Patients are eligible based on detection of these mutations in tumor tissue or plasma circulating tumor DNA (ctDNA) with a minimum variant allele frequency (VAF) of 1%
• DOSE EXPANSION COHORT 1: Histologically confirmed diagnosis advanced pancreatic cancer with KRAS G12C mutation. Patients must have progressed on at least 1 prior line of standard systemic therapy and must be eligible based on detection of KRAS G12C mutation in tumor tissue or ctDNA with a minimum VAF of 1%
• DOSE EXPANSION COHORT 2: Histologically confirmed diagnosis of advanced breast cancer with KRAS G12C mutation. Patients must have progressed on at least 1 prior line of standard systemic therapy and must be eligible based on detection of KRAS G12C mutation in tumor tissue or ctDNA with a minimum VAF of 1%
• DOSE EXPANSION COHORT 3: Histologically confirmed diagnosis of advanced uterine or epithelial ovarian cancer with KRAS G12C mutation. Patients must have progressed on at least 1 prior line of standard systemic therapy and must be eligible based on detection of KRAS G12C mutation in tumor tissue or ctDNA with a minimum VAF of 1%
• DOSE EXPANSION COHORT 4: Histologically confirmed diagnosis of NSCLC with KRAS G12C and KEAP1 co-mutations. Patients must have progressed on at least 1 prior line of standard systemic therapy and must be eligible based on detection of KRAS G12C and KEAP1 co-mutations in tumor tissue or plasma circulating tumor DNA (ctDNA) with a minimum VAF of 1%
• Unresectable or metastatic disease and for which standard curative or palliative measures do not exist or are no longer effective
• Patients must have evaluable or measurable disease per RECIST v1.1 for the dose escalation cohort and must have measurable disease per RECIST v1.1 for dose expansion cohorts 1-4
• Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
• Life expectancy of at least 3 months
• Most recent prior systemic therapy (e.g., chemotherapy, immunotherapy or, investigational agent) and radiation therapy discontinued at least 2 weeks before first dose date
• Eastern Cooperative Oncology Group (ECOG) performance status in 0 or 1
• Absolute neutrophil count >= 1.5 x 10^9/L
• Platelet count >= 100,000/mm^3 ( >= 100 x 10^9/L)
• Hemoglobin >= 10 g/dL, in the absence of transfusions for at least 28 days
• Total bilirubin =< 1.5 x upper limit of normal (ULN) (if associated with liver metastases or Gilbert's disease, =< 3 x ULN)
• Aspartate transaminase (AST) and alanine transaminase (ALT) =< 2.5 x ULN (if associated with liver metastases, =< 5 x ULN)
• Creatinine clearance >= 51mL/min calculated using a validated prediction equation
• The effects of adagrasib on the developing human fetus are unknown. For this reason and because the therapeutic agents used in this trial are known to be teratogenic, women and men, who are sexually active and of childbearing potential, must agree to use two highly effective forms of contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 6 months following termination of the study treatment. Female patients of non-childbearing potential must meet at least be one of the following: (i) postmenopausal (no menses in greater than or equal to 12 consecutive months); (ii) history of hysterectomy or bilateral salpingo-oophorectomy; (iii) ovarian failure (follicle stimulating hormone and estradiol in menopausal range, who have received whole pelvic radiation therapy); (iv) history of bilateral tubal ligation or another surgical sterilization procedure; (v) radiation-induced oophorectomy with last menses at least 1 year ago; and (vi) chemotherapy-induced menopause with at least 1 year interval since last menses. Approved methods of birth control are as follows: Hormonal contraception (i.e. birth control pills, injection, implant, transdermal patch, vaginal ring), intrauterine device (IUD), tubal ligation or hysterectomy, subject/partner post vasectomy, Implantable or injectable contraceptives, and condoms plus spermicide. Not engaging in sexual activity for the total duration of the trial and the drug washout period is an acceptable practice; however periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of birth control. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
• Men treated or enrolled on this protocol must also agree to use adequate contraception and avoid donating sperm prior to the study, for the duration of study participation, and 6 months after completion of the trial
• Prior treatment with a therapy targeting PARP or KRAS G12C mutation is permitted
• Ability to understand and the willingness to sign a written informed consent document
• Willing to comply with clinical trial instructions and requirements

Exclusion Criteria

• Active brain metastases. Patients are eligible if brain metastases are adequately treated and patients are neurologically stable (which is assessed in a case-by-case by the treating physician based on the likelihood of central nervous system [CNS] activity – except for residual signs or symptoms related to the CNS treatment - and by the lack of corticosteroid dosing or by having a stable or decreasing dose of =< 10 mg daily prednisone, or equivalent) for at least 2 weeks prior to enrollment
• Patients with carcinomatous meningitis
• Patients with myelodysplastic syndrome/acute myeloid leukemia or with features suggestive of myelodysplastic syndrome (MDS) / acute myeloid leukemia (AML)
• Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities > grade 1), excluding alopecia
• History of significant hemoptysis or hemorrhage within 4 weeks of the first dose date
• Undergone major surgery within 4 weeks of first dose date, or not recovered from any major surgery that occurred > 2 weeks before starting study treatment
• Undergone allogenic bone marrow transplant or double umbilical cord blood transplantation (dUCBT)
• History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions (e.g., uncontrolled nausea, vomiting, malabsorption syndrome) likely to alter absorption of study treatment or result in inability to swallow oral medications
• Any of the following cardiac abnormalities: * Unstable angina pectoris or myocardial infarction within 6 months prior to enrollment * Congestive heart failure New York Heart Association (NYHA) ≥ class 3 within 6 months prior to enrollment * Left ventricular ejection fraction (LVEF) < 50% * Corrected QT interval (QTc) > 480 milliseconds or medical or immediate family history of congenital long QT syndrome * Symptomatic or uncontrolled atrial fibrillation or other arrhythmia within 6 prior to enrollment * History of uncontrolled ventricular arrhythmia, recent (within 6 months) myocardial infarction
• History of stroke or transient ischemic attack within 6 months prior to enrollment
• Concomitant use of known strong CYP3A inhibitors or moderate CYP3A inhibitors. The required washout period prior to starting study treatment is 2 weeks
• Concomitant use of known strong or moderate CYP3A inducers. The required washout period prior to starting study treatment is 5 weeks
• Use of a medication with any of the following characteristics, which cannot be switched to an alternative treatment prior to study entry: * Substrate of P-gp with narrow therapeutic index * Strong inhibitor of breast cancer resistance protein (BCRP) * Proton pump inhibitor * Known risk of QT prolongation or Torsades de Pointes * Any substances listed as dietary restrictions
• Known or suspected presence of another malignancy, unless curatively treated, with no evidence of disease for ≥ 5 years with the exception of adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, ductal carcinoma in situ (DCIS), stage 1-grade 1 endometrial carcinoma
• Known history of human immunodeficiency virus (HIV) infection or acute or chronic hepatitis B or C infection. Note that the following are permitted: * Patients treated for hepatitis C with no detectable viral load; * Patients treated for HIV with no detectable viral load for at least 1 month prior to enrollment while on a stable regimen of agents that are not strong inhibitors of CYP3A4
• Pregnancy. Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy test documented within the 28-day screening period prior start of study drug
• Breast-feeding or planning to breast feed during the study or within 6 months after study treatment
• Any serious illness, uncontrolled inter-current illness, psychiatric illness, active or uncontrolled infection, or other medical history, including laboratory results, which, in the Investigator’s opinion, would be likely to interfere with the patient’s participation in the study, or with the interpretation of the results
• History of uncontrolled ventricular arrhythmia, recent (within 6 months) myocardial infarction, uncontrolled major seizure disorder, unstable spinal cord compression, superior vena cava syndrome, extensive interstitial bilateral lung disease on high resolution computed tomography (HRCT) scan
• Patients with a known hypersensitivity to olaparib or any of the excipients of the product