Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Inclusion Criteria

• * Any patient with UM or multiple uveal nevi, with at least one >= 3mm * Any patient with melanocytic atypical BAP1-negative cutaneous tumors (MBAITs) * Personal history of one cancer reported in BAP1 cancer predisposition syndrome and family history of at least two 1st or 2nd degree relatives with cancer reported in hereditary BAP1 cancer predisposition syndrome * Any patient with the diagnosis of breast cancer with family history of >= 2 breast cancers one of them =< 50 years old, who tested negative for mutation in BRCA1/BRCA2 genes or * Any patient with personal history of at least 2 cancers reported in hereditary BAP1 cancer predisposition syndrome